Compound IC50 [nM] α5β1 αvβ3 References (ref.; Compound name) 1 2,3

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Compound IC50 [nM] α5β1 αvβ3 References (ref.; Compound name) 1 2,3 3000 Heckmann, 2008; 44b Rechenmacher, 2013; 1 2 (K34c) 3,1 1624 Heckmann, 2008; 34c Martinkova , 2010; K34c Janouskova, 2013; K34c 3 108 0,65 Neubauer, 2014; 3 Supplementary Table 1. Structures and respective affinities of the different small non-peptidic compounds for α5β1 and αvβ3 integrins. References Heckmann et al, ChemBioChem, 2008, 9(9): 1397-1407. Janouskova et al, Cancer Letters, 2013, 336:307-318. Martinkova et al, Int. J. Cancer, 2010, 127:1240-1248. Neubauer et al, J. Med. Chem,, 2014, 57(8): 3410-3417. Rechenmacher et al, Angew.Chem.Int.Ed., 2013, 52: 1572-1575.