Arterioscler Thromb Vasc Biol

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Arterioscler Thromb Vasc Biol Effect of Low Dose Atorvastatin Versus Diet-Induced Cholesterol Lowering on Atherosclerotic Lesion Progression and Inflammation in Apolipoprotein E*3–Leiden Transgenic Mice by Lars Verschuren, Robert Kleemann, Erik H. Offerman, Alexander J. Szalai, Sjef J. Emeis, Hans M. G. Princen, and Teake Kooistra Arterioscler Thromb Vasc Biol Volume 25(1):161-167 January 1, 2005 Copyright © American Heart Association, Inc. All rights reserved.

Figure 1. Effect of atorvastatin on plasma lipids. Figure 1. Effect of atorvastatin on plasma lipids. A, Plasma cholesterol concentrations in apoE*3–Leiden mice over time (n=48 during run-in period and n=13 per group during experimental treatment period). B, Total cholesterol exposures after 16 weeks of treatment. C, Lipoprotein profiles of pooled plasma at 12 weeks. Data represent means±SD. *P<0.05 compared with HC. Lars Verschuren et al. Arterioscler Thromb Vasc Biol. 2005;25:161-167 Copyright © American Heart Association, Inc. All rights reserved.

Figure 2. Effect of atorvastatin on the progression of mild lesions. Figure 2. Effect of atorvastatin on the progression of mild lesions. A, Total cross-sectional lesion area in the aortic root in reference animals (n=9) and treatment groups (n=13). B, Effect of atorvastatin on the lesion number. Per mouse, 4 cross-sections with an interval of 30 μm were analyzed. C, The total plaque load in the aortic arch was analyzed by oil-red O-staining (n≥6). Data are presented as percentage of the stained area. D, Effect of atorvastatin on lesion severity in reference (n=9) and treatment groups (n=13). *P<0.05 compared with reference and #P<0.05 HC+A or LC vs HC. Lars Verschuren et al. Arterioscler Thromb Vasc Biol. 2005;25:161-167 Copyright © American Heart Association, Inc. All rights reserved.

Figure 3. Effect of atorvastatin on aspects of atherogenesis in the aortic root. Figure 3. Effect of atorvastatin on aspects of atherogenesis in the aortic root. Effect of atorvastatin on monocytes adhesion (A), macrophage content (B), SMC content (C) analyzed in reference (n=9) and treatment groups (n=11). *P<0.05 compared with reference, #P<0.05 HC+A or LC compared with HC, and &P<0.05 HC+A vs LC. Lars Verschuren et al. Arterioscler Thromb Vasc Biol. 2005;25:161-167 Copyright © American Heart Association, Inc. All rights reserved.

Figure 4. Effect of atorvastatin on plasma inflammation markers. Figure 4. Effect of atorvastatin on plasma inflammation markers. A, Effect of atorvastatin on plasma SAA (n≥11). *P<0.05 compared with reference and #P<0.05 HC+A or LC compared with HC. B, HuCRPtg mice received chow containing a low dose (LD; 0.002% [w/w]) or high dose (HD; 0.1% [w/w]) of atorvastatin or vehicle control (Con). huCRP levels were determined before treatment (t=0 weeks), after 3 weeks of atorvastatin treatment (basal), and 10 hours after an intraperitoneal injection of IL-1β (250 000 U per mouse). Data represent mean±SEM. *P<0.05 HD vs Con; **P<0.005 HD vs Con. Lars Verschuren et al. Arterioscler Thromb Vasc Biol. 2005;25:161-167 Copyright © American Heart Association, Inc. All rights reserved.