by Richard W. Troughton, Lynley K. Lewis, Timothy G. Yandle, A

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Presentation transcript:

Hemodynamic, Hormone, and Urinary Effects of Adrenomedullin Infusion in Essential Hypertension by Richard W. Troughton, Lynley K. Lewis, Timothy G. Yandle, A. Mark Richards, and M. Gary Nicholls Hypertension Volume 36(4):588-593 October 1, 2000 Copyright © American Heart Association, Inc. All rights reserved.

Facial flushing and conjunctival injection in a subject at the end of AM infusion (B) compared with the same time during vehicle control infusion (A). Facial flushing and conjunctival injection in a subject at the end of AM infusion (B) compared with the same time during vehicle control infusion (A). (Printed with permission of the subject.)‏ Richard W. Troughton et al. Hypertension. 2000;36:588-593 Copyright © American Heart Association, Inc. All rights reserved.

Plasma levels of AM, cAMP, BNP, ANP, and prolactin with AM and vehicle control infusions. Plasma levels of AM, cAMP, BNP, ANP, and prolactin with AM and vehicle control infusions. Results are mean±SEM (n=8). *P<0.05, +P<0.01, #P≤0.001. Richard W. Troughton et al. Hypertension. 2000;36:588-593 Copyright © American Heart Association, Inc. All rights reserved.

Levels of PRA, plasma angiotensin II, aldosterone, cortisol, norepinephrine, and epinephrine with AM and vehicle control infusions. Levels of PRA, plasma angiotensin II, aldosterone, cortisol, norepinephrine, and epinephrine with AM and vehicle control infusions. Results are mean±SEM (n=8). *P<0.05, +P<0.01. Richard W. Troughton et al. Hypertension. 2000;36:588-593 Copyright © American Heart Association, Inc. All rights reserved.

Hemodynamic effects of AM and vehicle control infusion. Hemodynamic effects of AM and vehicle control infusion. Results are mean±SEM (n=8). *P<0.05, +P<0.01, #P=<0.001. Richard W. Troughton et al. Hypertension. 2000;36:588-593 Copyright © American Heart Association, Inc. All rights reserved.

Baseline BP versus peak fall in BP and baseline calculated TPR versus peak fall in TPR in 8 normotensive control subjects and 8 patients with essential HT. Baseline BP versus peak fall in BP and baseline calculated TPR versus peak fall in TPR in 8 normotensive control subjects and 8 patients with essential HT. Richard W. Troughton et al. Hypertension. 2000;36:588-593 Copyright © American Heart Association, Inc. All rights reserved.