On the Replication of Genetic Associations: Timing Can Be Everything!

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On the Replication of Genetic Associations: Timing Can Be Everything! Jessica Lasky-Su, Helen N. Lyon, Valur Emilsson, Iris M. Heid, Cliona Molony, Benjamin A. Raby, Ross Lazarus, Barbara Klanderman, Manuel E. Soto-Quiros, Lydiana Avila, Edwin K. Silverman, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Florian Kronenberg, Caren Vollmert, Thomas Illig, Caroline S. Fox, Daniel Levy, Nan Laird, Xiao Ding, Matt B. McQueen, Johannah Butler, Kristin Ardlie, Constantina Papoutsakis, George Dedoussis, Christopher J. O'Donnell, H.-Erich Wichmann, Juan C. Celedón, Eric Schadt, Joel Hirschhorn, Scott T. Weiss, Kari Stefansson, Christoph Lange The American Journal of Human Genetics Volume 82, Issue 4, Pages 849-858 (April 2008) DOI: 10.1016/j.ajhg.2008.01.018 Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 1 Profile Plots of Body Mass Index by Age for CC and CT or TT Genotypes in FHS and CAMP These plots are presented for the two longitudinal studies that we have, FHS and CAMP. The left panel illustrates an initial increase in body mass index (BMI) for the CC genotype that diminishes by age 30 in the FHS. After age 8, the right panel also illustrates an increase in BMI associated with the CC genotype in CAMP. Prior to this age, our sample is limited in size, which is illustrated by the initial cross in genotypes. The American Journal of Human Genetics 2008 82, 849-858DOI: (10.1016/j.ajhg.2008.01.018) Copyright © 2008 The American Society of Human Genetics Terms and Conditions