Postmenopausal Women With Greater Paracardial Fat Have More Coronary Artery Calcification Than Premenopausal Women: The Study of Women's Health Across.

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Postmenopausal Women With Greater Paracardial Fat Have More Coronary Artery Calcification Than Premenopausal Women: The Study of Women's Health Across the Nation (SWAN) Cardiovascular Fat Ancillary Study by Samar R. El Khoudary, Kelly J. Shields, Imke Janssen, Matthew J. Budoff, Susan A. Everson‐Rose, Lynda H. Powell, and Karen A. Matthews J Am Heart Assoc Volume 6(2):e004545 January 29, 2017 © 2017 Samar R. El Khoudary et al.

Predicted geometric means of CAC extent by tertiles of PAT and E2 Predicted geometric means of CAC extent by tertiles of PAT and E2. *Adjusted for study site, race/ethnicity, age, menopausal status, obesity, systolic blood pressure, smoking, log triglycerides, medication use, hormone therapy use, cycle day of th... Predicted geometric means of CAC extent by tertiles of PAT and E2. *Adjusted for study site, race/ethnicity, age, menopausal status, obesity, systolic blood pressure, smoking, log triglycerides, medication use, hormone therapy use, cycle day of the blood draw. P=0.04 for interaction between PAT tertiles and E2 tertiles. P=0.004 for interaction between PAT and E2 as continuous measures. E2 tertile 1, n=79; E2 tertile 2, n=83; E2 tertile 3, n=51. PAT T1: ≥2.48 and ≤9.43 mm3; PAT T2: >9.43 and ≤16.02 mm3; PAT T3: >16.02 mm3. CAC indicates coronary artery calcification; EAT, epicardial adipose tissue; E2, estradiol; PAT, paracardial adipose tissue; PAT T1, first tertile of paracardial adipose tissue volume; PAT T2, second tertile of paracardial adipose tissue volume; PAT T3, third tertile of paracardial adipose tissue volume. Samar R. El Khoudary et al. J Am Heart Assoc 2017;6:e004545 © 2017 Samar R. El Khoudary et al.