Arterioscler Thromb Vasc Biol

Slides:

Advertisements

Similar presentations

Lipoprotein Metabolism And Disorders

Advertisements

بسم الله الرحمن الرحيم.

Lipoprotein Structures, Function and Metabolism (1)

Absorptive (fed) state

1 LIPID TRANSPORT Lipoproteins Lipids are transported in the blood as lipoproteins are soluble in water because the surface consists of polar lipids.

cardio protection: Focus on

L IPOPROTEINS. W HAT ARE LIPOPROTEINS ? Lipoproteins are molecules produced in the body and act as lipid transporters They consist of: Triglycerides Protein.

Date of download: 7/5/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effects of High vs Low Glycemic Index of Dietary Carbohydrate.

Copyright © 2016 McGraw-Hill Education. All rights reserved.

Hypercholesterolemia Enhances Thromboembolism in Arterioles but Not Venules by Martijn A.W. Broeders, Geert Jan Tangelder, Dick W. Slaaf, Robert S. Reneman,

Lipids in the diet are hydrolyzed in the small intestine, and the resultant fatty acids and monoglycerides are repackaged with apoB-48 into TG-enriched.

Lipoprotein Structure, Function, and Metabolism

Chapter 7 Metabolic syndrome

Arterioscler Thromb Vasc Biol

Amany K. Elshorbagy, Chris Church, Maria Valdivia-Garcia, A

Amany K. Elshorbagy, Chris Church, Maria Valdivia-Garcia, A

Volume 66, Issue 5, Pages (November 2015)

The effects of apo E alleles on various lipoprotein parameters

Fig. 2. Changes in the plasma glucose and NEFA levels

APOC3 LOF heterozygotes have lower IVD and IHD risks due to lower RC

Copyright © 2012 American Medical Association. All rights reserved.

Calcification burden of the femoropopliteal artery demonstrating progression from a healthy artery with no calcification (0) to advanced calcific deposits.

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

LIPIDS AND LIPOPROTEINS Dr. Gamal Gabr

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Behavior and Biology: The Basic Sciences for AHA Action

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Arterioscler Thromb Vasc Biol

Infusion of CSL112 increases total cholesterol efflux capacity (CEC) regardless of baseline functional apolipoprotein A-I (apoA-I) activity. Infusion of.

HIV Protease Inhibitors Stimulate Hepatic Triglyceride Synthesis

Arterioscler Thromb Vasc Biol

Review of Cholesterol and Lipoproteins

Figure 7 Mendelian randomization of overlapping exposures

Volume 23, Issue 3, Pages (March 2016)

Figure 2. Plasma lipoprotein cholesterol in apo-E −/− mice with CRF

HCV and the hepatic lipid pathway as a potential treatment target

Meredith Kilgore, PhD, Paul Muntner, PhD, J

بسم الله الرحمن الرحيم.

Dual Role of Circulating Angiopoietin-Like 4 (ANGPTL4) in Promoting Hypertriglyceridemia and Lowering Proteinuria in Nephrotic Syndrome Nosratola D.

Mikko Syvänne, MD, Marja-Riitta Taskinen, MD The Lancet

To B or Not to B: Is Non–High-Density Lipoprotein Cholesterol an Adequate Surrogate for Apolipoprotein B? Carl J. Lavie, MD, Richard V. Milani, MD, James.

Hajer GR et al. Atherosclerosis 2009;202:216-24

A whole body model for both glucose and fatty acid metabolism

Volume 130, Issue 1, Pages (January 2006)

New insights into lipid metabolism in the nephrotic syndrome

Assembly and secretion of apoB100- containing lipoproteins

(A) Low-density lipoprotein-cholesterol (LDL-C) values at baseline and after treatment with anagliptin in 20 participants at 12 and 24 weeks. (A) Low-density.

Lipoprotein Metabolism

Schematic representation of dyslipidaemia of metabolic syndrome.

H.N. Ginsberg, W.V. Brown. Arterioscler Thromb Vasc Biol 2011;31:

DPP4 release of explants obtained from adipose tissue of lean controls and obese patients before and after bariatric surgery, and linear correlation with.

Fig. 4 Deletion of hepatocyte HIF-2α does not affect obesity-induced glucose, glucagon, and insulin intolerance. Deletion of hepatocyte HIF-2α does not.

Effects of vinegar (□) and placebo (⧫) on plasma glucose (A–C) and insulin (D–F) responses after a standard meal in control subjects, insulin-resistant.

Plasma lipid exchange. Plasma lipid exchange. In the presence of increased concentrations of VLDL in the circulation, cholesteryl ester transfer protein.

Individual lipid measures for high-carbohydrate (n=10) and low-carbohydrate (n=10) ultra-endurance athletes. Individual lipid measures for high-carbohydrate.

Changes of major clinical and biochemical characteristics at baseline and during follow-up in different groups. Changes of major clinical and biochemical.

Presentation transcript:

Arterioscler Thromb Vasc Biol White Adipose Tissue Apolipoprotein C-I Secretion in Relation to Delayed Plasma Clearance of Dietary Fat in Humans by Hanny Wassef, Huda Salem, Simon Bissonnette, Alexis Baass, Robert Dufour, Jean Davignon, and May Faraj Arterioscler Thromb Vasc Biol Volume 32(11):2785-2793 October 17, 2012 Copyright © American Heart Association, Inc. All rights reserved.

Plasma concentrations of total triglyceride (A), glucose (B), nonesterified fatty acids (NEFA) (C), and insulin (D) after the ingestion of the 13C-triolein–labeled high-fat meal in women with high (n=9, solid line) vs low (n=10, dashed line) white adipose tissue (WAT) apolipoprotein (apo) C-I secretion. Plasma concentrations of total triglyceride (A), glucose (B), nonesterified fatty acids (NEFA) (C), and insulin (D) after the ingestion of the 13C-triolein–labeled high-fat meal in women with high (n=9, solid line) vs low (n=10, dashed line) white adipose tissue (WAT) apolipoprotein (apo) C-I secretion. Group differences are analyzed by repeated measures ANOVA. Hanny Wassef et al. Arterioscler Thromb Vasc Biol. 2012;32:2785-2793 Copyright © American Heart Association, Inc. All rights reserved.

Postprandial plasma concentrations of 13C-triglyceride (TG) (A), plasma concentration of 13C- nonesterified fatty acids (NEFA) (B), and percent of 13C recovered in breath (C) after the ingestion of the 13C-triolein–labeled high-fat meal in women with high (n=9, solid line) vs low (n=10, dashed line) white adipose tissue (WAT) apolipoprotein (apo) C-I secretion. Postprandial plasma concentrations of 13C-triglyceride (TG) (A), plasma concentration of 13C- nonesterified fatty acids (NEFA) (B), and percent of 13C recovered in breath (C) after the ingestion of the 13C-triolein–labeled high-fat meal in women with high (n=9, solid line) vs low (n=10, dashed line) white adipose tissue (WAT) apolipoprotein (apo) C-I secretion. Group differences are analyzed by repeated measures ANOVA. Hanny Wassef et al. Arterioscler Thromb Vasc Biol. 2012;32:2785-2793 Copyright © American Heart Association, Inc. All rights reserved.

Concentrations of fasting and 4-hour postprandial triglyceride (A, B), cholesterol (C, D), and apolipoprotein (apo) B (E, F) in the fast protein liquid chromatography–fractionated triglyceride-rich lipoproteins (TRL), intermediate-density lipoprotein (IDL)/low-density lipoprotein (LDL), and high-density lipoprotein (HDL) particles in women with high (n=9, solid line) vs low (n=10, dashed line) white adipose tissue (WAT) apoC-I secretion. $P<0.05 and $$P<0.01 for intrasubject postprandial differences from the fasting state. Concentrations of fasting and 4-hour postprandial triglyceride (A, B), cholesterol (C, D), and apolipoprotein (apo) B (E, F) in the fast protein liquid chromatography–fractionated triglyceride-rich lipoproteins (TRL), intermediate-density lipoprotein (IDL)/low-density lipoprotein (LDL), and high-density lipoprotein (HDL) particles in women with high (n=9, solid line) vs low (n=10, dashed line) white adipose tissue (WAT) apoC-I secretion. $P<0.05 and $$P<0.01 for intrasubject postprandial differences from the fasting state. Hanny Wassef et al. Arterioscler Thromb Vasc Biol. 2012;32:2785-2793 Copyright © American Heart Association, Inc. All rights reserved.

Correlation of fasting white adipose tissue (WAT) apolipoprotein (apo) C-I secretion over 4 hours with fasting concentrations, 4-hour postprandial concentrations, and 4-hour postprandial changes in total plasma apoC-I (A–C), non–high-density lipoprotein (HDL) apoC-I (D–F), and HDL apoC-I (G–I) in the 19 women examined (NB non-HDL apoC-I represents the sum of triglyceride-rich lipoprotein apoC-I and intermediate-density lipoprotein/low-density lipoprotein apoC-I). Correlation of fasting white adipose tissue (WAT) apolipoprotein (apo) C-I secretion over 4 hours with fasting concentrations, 4-hour postprandial concentrations, and 4-hour postprandial changes in total plasma apoC-I (A–C), non–high-density lipoprotein (HDL) apoC-I (D–F), and HDL apoC-I (G–I) in the 19 women examined (NB non-HDL apoC-I represents the sum of triglyceride-rich lipoprotein apoC-I and intermediate-density lipoprotein/low-density lipoprotein apoC-I). Hanny Wassef et al. Arterioscler Thromb Vasc Biol. 2012;32:2785-2793 Copyright © American Heart Association, Inc. All rights reserved.

Correlation of 6-hour area under the curve (AUC6hours) of plasma 13C-triglyceride (TG) with fasting plasma triglyceride-rich lipoprotein (TRL) apolipoprotein (apo) C-I (A), intermediate-density lipoprotein (IDL)/low-density lipoprotein (LDL) apoC-I (B), high-density lipoprotein (HDL) apoC-I (C), and total apoC-I (D) in the 19 women examined. Correlation of 6-hour area under the curve (AUC6hours) of plasma 13C-triglyceride (TG) with fasting plasma triglyceride-rich lipoprotein (TRL) apolipoprotein (apo) C-I (A), intermediate-density lipoprotein (IDL)/low-density lipoprotein (LDL) apoC-I (B), high-density lipoprotein (HDL) apoC-I (C), and total apoC-I (D) in the 19 women examined. Hanny Wassef et al. Arterioscler Thromb Vasc Biol. 2012;32:2785-2793 Copyright © American Heart Association, Inc. All rights reserved.

Fasting white adipose tissue (WAT) secretion of apolipoprotein (apo) C-I, apoC-II, apoC-III, and apoE over 24 hours (A), correlation of 24-hour WAT secretion of apoC-III with apoC-II (B), correlation of 6-hour area under the curve (AUC6hours) of plasma 13C-triglyceride (TG) with 24-hour WAT apoC-I secretion (C), and correlation of AUC6hours of plasma 13C-TG with the ratio of 24-hour WAT secretion of apoC-I:apoC-II (D) in the 19 women examined. **P<0.01 and ***P<0.001. Fasting white adipose tissue (WAT) secretion of apolipoprotein (apo) C-I, apoC-II, apoC-III, and apoE over 24 hours (A), correlation of 24-hour WAT secretion of apoC-III with apoC-II (B), correlation of 6-hour area under the curve (AUC6hours) of plasma 13C-triglyceride (TG) with 24-hour WAT apoC-I secretion (C), and correlation of AUC6hours of plasma 13C-TG with the ratio of 24-hour WAT secretion of apoC-I:apoC-II (D) in the 19 women examined. **P<0.01 and ***P<0.001. Hanny Wassef et al. Arterioscler Thromb Vasc Biol. 2012;32:2785-2793 Copyright © American Heart Association, Inc. All rights reserved.