Evidence of pleiotropy by statins: Leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical.

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Evidence of pleiotropy by statins: Leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors Ping-Yen Liu, Po-Tseng Lee, Wei-Ting Chang, Yun-Ling Tai, Ting-Hsing Chao, Cheng-Han Lee, Yi-Heng Li, Jyh-Hong Chen, Liang-Miin Tsai, James K. Liao International Journal of Cardiology Volume 176, Issue 1, Pages 250-253 (September 2014) DOI: 10.1016/j.ijcard.2014.06.059 Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Serial changes of biochemical markers before and after PCI. (A) and (B): Troponin-T and C-reactive protein (CRP) elevated significantly only at 24h after PCI. (C): Rho kinase (ROCK) activity on isolated peripheral leukocytes increased immediately after PCI and persistent till 24h after PCI. (D): Pretreated statin subgroup showed less elevation of C-reactive protein (CRP) at 24h after PCI than the statin naïve subgroup. (E): Pretreated statin showed less elevation of Rho kinase (ROCK) activity elevation on isolated peripheral leukocytes both immediately after PCI and also at 24h after PCI than the statin naïve subgroup. PCI=percutaneous coronary intervention; p-MBS=phosphor-myosin binding subunit; t-MBS=total myosin binding subunit. International Journal of Cardiology 2014 176, 250-253DOI: (10.1016/j.ijcard.2014.06.059) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Kaplan–Meier survival curve of the proportion of patients remaining free of subsequent coronary events after PCI (A): Baseline leukocyte Rho kinase (ROCK) activity on isolated peripheral leukocytes (cutoff value: 0.38 (pMBS/tMBS ratio from Western blot)); (B) level of ROCK activity after PCI (cutoff value: 0.9); (C): pretreated statin or not; (D): subanalysis according to the level of ROCK activity after PCI (cutoff value: 0.9 (pMBS/tMBS ratio from Western blot)) and the pretreatment of statin or not. *P<0.05. PCI=percutaneous coronary intervention. International Journal of Cardiology 2014 176, 250-253DOI: (10.1016/j.ijcard.2014.06.059) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions