دورة كريبس Dr. Zelal Alsaftli Animal Production Department Agriculture College Hama University.

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دورة كريبس Dr. Zelal Alsaftli Animal Production Department Agriculture College Hama University

CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH 2 mole Pyruvic acid 2 mole Acetyl CoA

CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH 2 mole Pyruvic acid 2 mole Acetyl CoA

CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH Pyruvic acid Acetyl CoA CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH Pyruvic acid Acetyl CoA CHO (HCOH) 4 CH2OH Glucose + 6 C 3+3 C 2+2 C C 6 H 12 O 6 C6H8O6C6H8O6C6H8O6C6H8O6 C4H6O2C4H6O2C4H6O2C4H6O2 - 4 H - 2 H - 4 O

CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH Pyruvic acid Acetyl CoA CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH Pyruvic acid Acetyl CoA CHO (HCOH) 4 CH2OH Glucose + 6 C 3+3 C 2+2 C C 6 H 12 O 6 C6H8O6C6H8O6C6H8O6C6H8O6 C4H6O2C4H6O2C4H6O2C4H6O2 - 4 H - 2 H - 4 O

CO 2 دورة كريبس من حيث ذرات الكربون

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH C 4 C 6 C 5 C 4 C

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH حمض الستريك حمض السكسنيك حمض فوماريك حمض ماليك

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH دورة الأحماض ثلاثية الكربوكسيل

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH عدد مولات ATP الناتجة خلال دورة كريبس = 4 × 3 = 12 ولكن لدينا 2 مول بيروفيك من 1 جلوكوز وبالتالي = 12 × 2 = 24 مول ATP عدد مولات ATP الناتجة خلال دورة كريبس = 4 × 3 = 12 ولكن لدينا 2 مول بيروفيك من 1 جلوكوز وبالتالي = 12 × 2 = 24 مول ATP

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH

CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH

جلوكوز بيروفيك استيل كو أ 8 ATP 3ATP 38 ATP 3ATP كريبس. 12ATP

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