Chlamydocin Chlamydocin is a cyclic tetrapeptide. Chlamydocin is a very potent inhibitor of cell proliferation. Chlamydocin was shown to be a very potent.

Slides:

Advertisements

Similar presentations

Does your DNA define you? Overview of epigenetics and its role in disease.

Advertisements

Mesothelioma: your questions and future treatment options Susie Harden 1/4/11.

Katherine Tai Mentor: Mohaiza Dashwood Advisor: Rod Dashwood Department of Environmental & Molecular Toxicology Linus Pauling Institute.

Retinoic Acid Receptor Alpha and Acute Promyelocytic Leukemia Nidhi Thapar April 1, 2004.

Co-supervisor: Prof Richard Lock

 Dr. Steven Grant  Dr. Roberto Rosato  Jorge Almenara  Stefanie Coe  Dr. Allison Johnson, HHMI Coordinator.

Afsha Rais.  In chromatins, DNA is wrapped around proteins of which most are histones.  Histones assist in DNA packaging and have a regulatory role.

Mudit Tyagi George Mason University, Manassas, Virginia, USA CBF-1 induces both establishment and maintenance of HIV latency via recruiting PcG corepressor.

Volume 30, Issue 3, Pages (September 2016)

Aromatase Inhibitors. Aromatase Inhibitors.

Featured Inhibitors for October-BOC Sciences

Targeting the PARP DNA repair pathway enhanced cytotoxicity induced by chemotherapy. Targeting the PARP DNA repair pathway enhanced cytotoxicity induced.

Didac Carmona-Gutierrez, Frank Madeo Molecular Cell

Intrinsic factors regulating stem cell self‐renewal.

Targeting Epigenetics to Speed Up Repair

Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway.

HDAC Dependent Transcriptional Repression of Bmp-7 Potentiates TGF-β Mediated Renal Fibrosis in Obstructive Uropathy Scott R. Manson, Joseph B. Song,

Apoptosis: Does stress kill?

Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and.

F-Class Cells: New Routes and Destinations for Induced Pluripotency

Volume 130, Issue 7, Pages (June 2006)

Schematic representation of brain targets common to the neurobiology and pharmacology of epilepsy and aggression. Schematic representation of brain targets.

Cell signaling and cancer

Mechanisms of apoptosis and growth arrest by isothiocyanates.

A Histone Deacetylase Inhibitor LBH589 Downregulates XIAP in Mesothelioma Cell Lines Which is Likely Responsible for Increased Apoptosis With TRAIL James.

Making Sense of HDAC2 Mutations in Colon Cancer

Figure 4 Potential therapeutic strategies to inhibit TGF-β1/Smad-induced tissue fibrosis Figure 4 | Potential therapeutic strategies to inhibit TGF-β1/Smad-induced.

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Volume 42, Issue 2, Pages (February 2005)

EGFR signaling in renal fibrosis

RAS/RAF pathway-activated ovarian cancer cells exhibit MEK dependence and synergistic induction of apoptosis with combined MEK/AKT inhibition. RAS/RAF.

Volume 73, Issue 1, Pages 1-3 (January 2012)

B A D C * * E F Panc-1 cells Figure S1 DNA ladder h

The Epigenomics of Cancer

BCL11B-Mediated Epigenetic Repression Is a Crucial Target for Histone Deacetylase Inhibitors in Cutaneous T-Cell Lymphoma Wenjing Fu, Shengguo Yi, Lei.

Volume 22, Issue 4, Pages (April 2015)

Edwina S. Baskin–Bey, Gregory J. Gores Gastroenterology

H.B. Lee, H. Noh, J.Y. Seo, M.R. Yu, H. Ha Kidney International

Regulation of oligodendrocyte differentiation: Insights and approaches for the management of neurodegenerative disease Abdullah Mohammad Tauheed, Joseph.

AChE (Acetylcholinesterase) inhibitor

Volume 19, Issue 6, Pages (June 2012)

High-throughput combination drug screening to nominate potent drug combinations. High-throughput combination drug screening to nominate potent drug combinations.

Prediction of novel cell cycle inhibitors based on CODIM1.

Volume 73, Issue 1, Pages 5-7 (January 2008)

NM-3 induces p21 levels and down-regulation of Cdk2 activity.

Volume 30, Issue 3, Pages (September 2016)

Volume 22, Issue 2, Pages (February 2015)

Apoptotic insults to human HepG2 cells induced by S-(+)-ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway S.-T. Lee,

Characteristics of the Study Subjects

The series of stem cell Season Ⅱ

Schematic representation of signaling by high-risk human papillomavirus HPV E7. Schematic representation of signaling by high-risk human papillomavirus.

Metabolic Homeostasis: HDACs Take Center Stage

Volume 129, Issue 7, Pages (June 2007)

Protein expression profiling of small cell lung carcinoma treated with valproic acid (VPA) and VAC (mafosfamide, doxorubicin and vindesine). Protein expression.

BCL11B-Mediated Epigenetic Repression Is a Crucial Target for Histone Deacetylase Inhibitors in Cutaneous T-Cell Lymphoma Wenjing Fu, Shengguo Yi, Lei.

Epithelial to Mesenchymal Transition in an Epidermal Growth Factor Receptor-Mutant Lung Cancer Cell Line with Acquired Resistance to Erlotinib Kenichi.

Distinguished Lecture Series

Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial.

Fig. 3. Inactivation of the Wnt/β-catenin signaling pathway inhibited cell proliferation and induced apoptosis in A549 and SPC-A-1 cells. Inactivation.

Fig. 5. Combination of SAHA and ML produces augmented suppression of cellular proliferation with impaired cell cycle progression, enhanced apoptotic.

A Stepping Stone to Pluripotency

Protective effect of inhibitors of neuronal toxicity of glutamate analog (HCA) in erastin-induced death in HT1080 cells. Protective effect of inhibitors.

Ectopic expression of caveolin-1 in ZR75 human breast cancer cells downregulated survivin and decreased cell proliferation. Ectopic expression of caveolin-1.

Brain regions displaying enhanced histone acetylation following fear extinction and fear learning Published studies have revealed that successful fear.

by Abigail M. Druck Shudofsky, and Chou-Zen Giam

Compounds acting on pathogenic pathways of pulmonary arterial hypertension. Compounds acting on pathogenic pathways of pulmonary arterial hypertension.

Fig. 2. Scriptaid and RGFP966 alter macrophage phenotype

Potential model of HMQ1611 inhibiting breast cancer cell proliferation

CREBBP inactivation disables acetylation and results in unopposed deacetylation by the BCL6/SMRT/HDAC3 complex, which disrupts enhancer activity in B cells.

Histone deacetylase inhibitors in cancer therapy

Presentation transcript:

chlamydocin Chlamydocin is a cyclic tetrapeptide. Chlamydocin is a very potent inhibitor of cell proliferation. Chlamydocin was shown to be a very potent histone deacetylase (DDAC) inhibitor with an IC50 value of 1.3 nM. Some data also indicate a potential link between degradtation of survivin and activation of the apoptotic pathway induced by HDAC inhibitors.