A Multidisciplinary Team Approach Challenges and Best Practices in Cushing Disease

Program Goals

Patient Case 39-Year-Old Woman

Patient Case (cont)

Cushing Disease Clinical Features

Cushing Disease Biochemical Diagnosis

Patient Case Laboratory Findings

Establishing the Source of ACTH Excess

Managing Patient Expectations Post-Operatively

Patient Case Post-Op Course

Patient Case 3 Years Later…

Does the Patient Have Recurrent Cushing Disease?

Recurrent Cushing Disease Treatment Targets and Options

Adrenal Steroidogenesis Inhibitors*

Cabergoline* Dopamine Agonist

Absolute Change in UFC Levels From Baseline to Month 6 With Pasireotide

Pasireotide Adverse Events Hyperglycemia

Mifepristone

Mifepristone Adverse Events and Monitoring

Emerging Agents Target Adrenal Steroidogenesis

Radiation Therapy and Radiosurgery

Bilateral Adrenalectomy