A.C. Abraham, H.M. Pauly, T.L. Haut Donahue

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General Information Osteoarthritis and Cartilage

Presentation transcript:

Deleterious effects of osteoarthritis on the structure and function of the meniscal enthesis A.C. Abraham, H.M. Pauly, T.L. Haut Donahue Osteoarthritis and Cartilage Volume 22, Issue 2, Pages 275-283 (February 2014) DOI: 10.1016/j.joca.2013.11.013 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Schematic of sample location. AD sections used for histomorphometry. AB sections used for indentation and μCT. Inset – Meniscal enthesis stained with TB/VK to highlight the four unique regions: LI, UFC, CFC, and SB. Yellow lines highlight the demarcations between zones. Yellow dots represent location of indentation test points. Osteoarthritis and Cartilage 2014 22, 275-283DOI: (10.1016/j.joca.2013.11.013) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Pathophysiology in meniscal entheses due to OA. Healthy entheses have a smooth, intact TM (A) and are free from calcium deposits within the LI portion (B). Osteoarthritic meniscal entheses exhibited degenerative signs similar to other entheses such as calcium deposits within the LI zone (C), double TM formation (D), osteophyte formation (E), and microcracks/fissuring (F). Osteoarthritis and Cartilage 2014 22, 275-283DOI: (10.1016/j.joca.2013.11.013) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Results of fitting the sigmoidal Gompertz function to the mineral density as a function of relative position across the enthesis. Osteoarthritis and Cartilage 2014 22, 275-283DOI: (10.1016/j.joca.2013.11.013) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Instantaneous elastic modulus as function of relative distance from the TM. Several locations within the fibrocartilaginous zones were significantly more compliant in the arthritic LA, MA, and medial posterior entheses. * – represents significant difference (P < 0.05) between healthy and OA tissue for a specific location. Moduli presented as means with 95% confidence interval (N = 7 OA knees, N = 8 healthy knees, n = 15 locations per enthesis). Osteoarthritis and Cartilage 2014 22, 275-283DOI: (10.1016/j.joca.2013.11.013) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Equilibrium elastic modulus as function of relative distance from the TM. Several locations within the fibrocartilaginous zones were significantly more compliant in the arthritic LA, MA, and medial posterior entheses. * – represents significant difference (P < 0.05) between healthy and OA tissue for a specific location. Moduli presented as means with 95% confidence interval (N = 7 OA knees, N = 8 healthy knees, n = 15 locations per enthesis). Osteoarthritis and Cartilage 2014 22, 275-283DOI: (10.1016/j.joca.2013.11.013) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions