65 year-old female with Alzheimer’s disease Lananh Nguyen, M.D. Division of Neuropathology University of Pittsburgh Medical Center

An autopsy was performed. Identify the structures arrow.

Lateral geniculate nucleus An autopsy was performed. Identify the structures arrow. Corpus callosum Caudate, tail Thalamus Lateral geniculate nucleus Hippocampus

Note the atrophy in the brain with the Alzheimer’s disease. Normal Severe atrophy library.med.utah.edu

What microscopic pathology is in abundance in Alzheimer’s disease (AD)?

What microscopic pathology is in abundance in Alzheimer’s disease (AD)? Neuritic plaques Neurofibrillary tangles Amyloid plaques

What stains would you use to evaluate microscopic pathology in Alzheimer’s disease (AD) for these features? Neuritic plaques Neurofibrillary tangles Amyloid plaques

What stains would you use to evaluate microscopic pathology in Alzheimer’s disease (AD) for these features? Neuritic plaques : Bielchowsky stain Neurofibrillary tangles: Phosphorylated tau stain Amyloid plaques: Beta amyloid stain

What “body” would you expect to see in the hippocampus of a person with AD Hirano bodies

Where in the hippocampus can you find these bodies?

Where in the hippocampus can you find these bodies? CA1 region of the hippocampus CA3 CA2 CA4 CA1 Dentate gyrus

What are the 4 most common genes linked to AD? Amyloid precursor protein mutation (causative gene) Presenilin 1 and Presenilin 2 mutations (causative gene) Apolipoprotein E4 (risk gene)