Figure Comparative myopathology of immune myopathies with perimysial pathology (IMPP) and dermatomyositis with vascular pathology (DM-VP)‏ Comparative.

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Presentation transcript:

Figure Comparative myopathology of immune myopathies with perimysial pathology (IMPP) and dermatomyositis with vascular pathology (DM-VP)‏ Comparative myopathology of immune myopathies with perimysial pathology (IMPP) and dermatomyositis with vascular pathology (DM-VP) IMPP myopathology includes perimysium that is widened and damaged (A; H&E stain), occupied by histiocytic cells (C; acid phosphatase stain), and stained by alkaline phosphatase (E). Muscle fiber damage includes necrosis, (membrane attack complex [C5b-9] deposited in fiber cytoplasm [G]), more prominent near the perimysium. DM-VP myopathology includes muscle fiber pathology with perifascicular atrophy without necrosis (B; H&E stain) and metabolic changes, including reduced staining on cytochrome oxidase (H). DM-VP vascular pathology includes perivascular (perimysial) lymphocytic inflammation (D; Congo red stain) and endomysial capillary changes with increased alkaline phosphatase staining (F). Scale bar = 100 μM (Panels A–H). Robert C. Bucelli, and Alan Pestronk Neurol Neuroimmunol Neuroinflamm 2018;5:e434 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.