Hydrogels / Applications in Opthamology Frequently, presenters must deliver material of a technical nature to an audience unfamiliar with the topic or vocabulary. The material may be complex or heavy with detail. To present technical material effectively, use the following guidelines from Dale Carnegie Training®.   Consider the amount of time available and prepare to organize your material. Narrow your topic. Divide your presentation into clear segments. Follow a logical progression. Maintain your focus throughout. Close the presentation with a summary, repetition of the key steps, or a logical conclusion. Keep your audience in mind at all times. For example, be sure data is clear and information is relevant. Keep the level of detail and vocabulary appropriate for the audience. Use visuals to support key points or steps. Keep alert to the needs of your listeners, and you will have a more receptive audience. 11/6/2018

Polyelectrolyte Hydrogels Hydrophilic polymer chains containing positive or negatively charged functional groups that interact electrostatic interactions to form a cross-linked network that attracts water 11/6/2018

Hylauronic Acid 11/6/2018

Polyelectrolyte Multilayers Layer by layer deposition 11/6/2018

Alginate gels 11/6/2018

Enzyme Immobilization 11/6/2018

Cell Encapsulation 11/6/2018

Alginate gels 11/6/2018

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Alginate gels 11/6/2018

Applications artificial tendon and cartilage wound healing dressings (Vigilon®, Hydron®, Gelperm®) non-antigenic, flexible wound cover permeable to water and metabolites low-strength artificial kidney membranes artificial skin maxillofacial and sexual organ reconstruction materials vocal cord replacement 11/6/2018

Corning® Ultra Low Attachment Products Unique hydrogel surface inhibits cell attachment                                                        11/6/2018

Hydrogels: Applications Earliest biomedical application contact lenses good mechanical stability favorable refractive index high oxygen permeability needs hygienic maintenance unable to correct for astigmatism 11/6/2018

Acrylates 11/6/2018

Methacrylates 11/6/2018

Poly(methyl methacrylate) 11/6/2018

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Poly(2-hydroxyethylmethacrylate pHEMA 11/6/2018

Hydrogels: PHEMA The most widely used hydrogel water content similar to living tissues inert to biological processes shows resistance to degradation permeable to metabolites not absorbed by the body withstands sterilization by heat prepared in various shaped and forms 11/6/2018

Contact lens PMMA HEMA Fabrication methods Computer assisted cutting (lathe)-PMMA rods Spin casting-polymerization Molding-polymerization 11/6/2018

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Intraocular lens PMMA HEMA Polymer backbone - mixture of PMMA and PHEMA Varying water contents Additives such as UV blockers 11/6/2018

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Foldable IOL complications/explantations - 11/6/2018

Reasons for Revision Surgery Incorrect lens power seen most commonly Glare/optical aberrations Dislocation/decentration Late postoperative opacification 11/6/2018

IOL Optic Opacification Surface opacification Opacification within the substance of the optic Analysis of opacifications reveals presence of calcium Calcium staining Scanning electron microscopic analysis 11/6/2018

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Accommodative IOL: 1CU (HumanOptics) Total diameter: 9.7 mm 11/6/2018