Joseph P. Kolb, Jennifer Martinez  Immunity 

Slides:



Advertisements
Similar presentations
Bacterial Entry to the Splenic White Pulp Initiates Antigen Presentation to CD8+ T Cells Taiki Aoshi, Bernd H. Zinselmeyer, Vjollca Konjufca, Jennifer.
Advertisements

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Meghan A. Koch, Kerri R. Thomas, Nikole R.
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,
Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming Smita Srivastava, Joel D. Ernst Cell Host & Microbe Volume 15, Issue 6,
“Toll”-erance in the Skin
The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response
Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges
Cytokines, Skin, and Smallpox–A New Link to an Antimicrobial Peptide
Bridget A. Robinson, Timothy J. Nice  Immunity 
HIV-1 Latency by Transition
An Activation Marker Finds a Function
Tiffany Bouchery, Nicola L. Harris  Immunity 
The Leptin Connection: Regulatory T Cells and Autoimmunity
PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria
Immobile BCRs: The Safety on the Signal Trigger
Toll-like Receptors Keep Antigen Sorting on the Right Track
Distinct Mechanisms of Tumor Resistance to NK Killing: Of Mice and Men
Toll-like Receptor 9, What O'Clock Is It?
Some DCs Are “B”etter Immunity
Notch: Filling a Hole in T Helper 2 Cell Differentiation
Autophagy Meets Phagocytosis
Taking T Cell Priming Down a Notch: Signaling through Notch Receptors Enhances T Cell Sensitivity to Antigen  Timothy J. Thauland, Manish J. Butte  Immunity 
A Flt3L Encounter: mTOR Signaling in Dendritic Cells
T Helper 17 Cells Get the NOD
Checks and Balances: IL-23 in the Intestine
More Is Less: IL-9 in the Resolution of Inflammation
Foxo1 and Foxo3 help Foxp3 Immunity
Sweet NETs, Bitter Wounds
Thymic Selection: To Thine Own Self Be True
Arming Treg Cells at the Inflammatory Site
Shannon M. Kahan, Allan J. Zajac  Immunity 
Amyloid Cascade into Clarity
Volume 26, Issue 3, Pages (March 2007)
Michelle A. Linterman, Alice E. Denton  Immunity 
BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens
Ubiquitin-Proteasome: Pallbearer Carries the Deceased to the Grave
The Silent Undertakers: Macrophages Programmed for Efferocytosis
John G. Monroe, Mary E. Keir  Immunity 
Metabolic Connections during Apoptotic Cell Engulfment
Thomas S. Griffith, Thomas A. Ferguson  Immunity 
Why Worms Watch Their Hemidesmosomes and Why You Should, Too
Taia T. Wang, Jeffrey V. Ravetch  Immunity 
PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria
More Is Less: IL-9 in the Resolution of Inflammation
IL-1 Can Act as Number One
Dynamic Encoding in the Notch Pathway
Volume 30, Issue 2, Pages (February 2009)
Volume 38, Issue 1, Pages (January 2013)
Cigarette Smoke Resets the Alarmin IL-33 in COPD
Michelle A. Linterman, Alice E. Denton  Immunity 
Compliments of Factor H: What’s in it for AMD?
Tissue protection by erythropoietin: new findings in a moving field
Volume 35, Issue 4, Pages (October 2011)
Licensing PPARγ to Work in Macrophages
Recycling Endosomes and TLR Signaling— The Rab11 GTPase Leads the Way
t Testing the Immune System
Some DCs Are “B”etter Immunity
At 17, In-10's Passion Need Not Inflame
Oxygenated Lipids: A Mode to WiPE Out Inflammation?
Identity Crisis: It’s Not Just Foxp3 Anymore
Volume 27, Issue 5, Pages (November 2007)
Why Worms Watch Their Hemidesmosomes and Why You Should, Too
Marking Emerging β- and γδ-Selected T Cells
IL-9 by INFERence Immunity
T Helper Cell Differentiation: Understanding the Needs of Hierarchy
Presentation transcript:

Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage’s Appetite for Apoptotic Cells  Joseph P. Kolb, Jennifer Martinez  Immunity  Volume 44, Issue 2, Pages 209-211 (February 2016) DOI: 10.1016/j.immuni.2016.01.023 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The “Find-Me” Signal S1P Activates the EPO-EPOR Axis to Prime Macrophages for Efferocytosis Release of the “find-me” signal, S1P, by dying cells upregulates EPO expression in phagocytic cells, such as macrophages. Signaling via the EPO-EPOR axis activates the PPARγ pathway, which increases levels of phagocytic receptors, such as MFGE8, MerTK, CD36, and Gas6. Mice in which EPO-EPOR signaling is disrupted display decreased clearance of dying cells and increased incidence of autoimmunity. Immunity 2016 44, 209-211DOI: (10.1016/j.immuni.2016.01.023) Copyright © 2016 Elsevier Inc. Terms and Conditions

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.