Innate Immunity Hugh B. Fackrell.

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Presentation transcript:

Innate Immunity Hugh B. Fackrell

Innate Immunity Assigned Reading Content Outline Performance Objectives Key terms Key Concepts Short Answer Questions Next

Assigned Readings Innate immunity 6-11 Phagocytic deficiences 507-511 Complement 348-353 Lysozyme 8, 10 Interferon (INF) 460-461, 590-591, 373-375 Tumour necrosis factor (TNF) 370-375 NK Cells 387-390 NK Cells and TNF 391 Next

Content Outline Definitions Exterior Defenses Interior Defenses Soluble factors Lysozyme, interferon, complement Cells Phagocytes, natural killer cells Inflammation chemotaxis, diapedisis, phagocytosis Next

Innate Immunity: Definition AKA non adaptive immunity Non specific Constant Those factors that are ALWAYS present to defend the body against infection

Adaptive Vs Innate Immunity

Defensive Barriers Anatomic Physiologic Phagocytic & Endocytic Inflammatory Next

Exterior Defenses

Interior Defenses: Soluble Factors Lysozyme Interferon Complement Cells Inflammation Next

Lysozyme

Lysozyme Molecule Lysozyme.pdb

Interferon

Complement functions

Interior Defenses: Cells Soluble Factors Cells Phagocytes Natural killer cells Inflammation Next

Phagocytes: Distribution

Monocyte

Neutrophil

Null Cell

Perforin Pores

Cytotoxic cell: Pore formation

Video of Cytotoxic Lymphocytes Click on icon to activate video

Interior Defenses: Inflammation Soluble Factors Cells Inflammation Chemotaxis Diapedesis Phagocytosis Next

Monocyte Movement

Leucocyte adherance

Chemotaxis

Diapedesis

Macrophage Pseudopodia

Neutrophil phagocytosis

Phagocytosis

Video of Phagocytosis Click on icon to activate video

Summary: Adaptive vs Innate Immunity

The End

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