Department of Medicine Faculty Meeting March 25, 2018 Announcements Multidisciplinary Training Program in CV Epidemiology: Vanessa Xanthakis Pulmonary Embolism Response Team: Ashvin Pande

Announcements Section Chief retreat Thursday, April 26, 2018 David Salant, M.D. to remain as Chief, Renal Section until his replacement is hired BU Technology Wonders: Potential Biomedical Applications, March 28, 2-5 pm, EBRC 714 Budget update

Match Highlights Number of students matching in medicine increased from 6300 to 7500 in 2018 4800 applicants to our program 405 applicants interviewed, 390 ranked Filled 40 Categorical, 5 PC, 8 prelims 9.4% URM’s Among best match results in past several years

Faculty Development Seminars How to Fall in Love with Your Job Again Sheila Chapman, Hasmeena Kathuria, Hee-Young Park April 3rd from 12-1pm in Wilkins How to Get Your Education Project Published: Part 1 Bob Vinci April 12th from 12-1pm in Yawkey Basement Conference Room

Grand Rounds March 30th Tuberculosis: It's Not Just an Infectious Disease Natasha Hochberg, MD Assistant Professor, Department of Medicine, Section of Infectious Diseases   April 6th Beldon Idelson Memorial Lecture State-of-the-Art Approaches to ANCA Small Vessel Vasculitis Dr. Ronal J Falk Chair of Medicine at the University of North Carolina April 13th Philip Kramer Lecture Eosinophilic Esophagitis and PPI-Responsive Esophageal Eosinophilia Dr. Rhonda Souza April 20th Clinical/Research A Mighty Trio: Thrombosis, Atrial Fibrillation and Stroke, from bench to bedside Drs. Katya Ravid, Elaine Hylek, and Emelia Benjamin April 27th Faulkner Lecture Cynthia Boyd, MD, MPH Professor of Medicine, Center for Transformative Geriatric Research, Department of Medicine Johns Hopkins University School of Medicine May 4th Gary Garber Grand Rounds May 11th Topic: TBD Dr. Paul Aronowitz May 18th The Heart in Metabolic Syndrome: Mitochondria in Distress – From Bench to Bedside Drs. Wilson Colucci and Markus Bachschmid May 25th (last Grand Rounds) SRAD

Faculty Development Seminars CV Boot Camp A&P Committee Members April 19th from 5-6pm in Wilkins Assessment in Medical Education & Survey Design Priya Garg May 1st from 12-1pm in Wilkins

Faculty Grants Faculty Development & Diversity Grants Open to ALL DOM FACULTY at all levels seeking to further their professional development in research, education, clinical skills, and/or leadership Next deadline is April 15th http://www.bumc.bu.edu/facdev-medicine/grants/

Faculty Grants Education Pilot Grants $1000 - $5000 grants to fund innovative projects and research in education Grant recipients participate in a 6-session writing course to support their project & manuscript development Deadline is May 1, 2018 http://www.bumc.bu.edu/facdev-medicine/grants/education-pilot-grants/

Women’s Leadership Program Target Audience BUMC women faculty in leadership roles Number of Faculty Up to 20 per year Program Structure Meets for 15 two-hour sessions from September to June Program Elements Experiential seminars on leadership skills and fostering change as a woman leader Peer mentoring & coaching to successfully negotiate challenges, foster resiliency, and achieve goals Conversation Cafes with inspirational leaders Applications accepted March 19th – April 16th, 2018

URM Faculty Development Program Target Audience BUMC under-represented minority in medicine* faculty Number of Faculty Up to 20 per year Program Structure Meetings monthly for 1.5 hours from October - June Program Elements Experiential seminars focused on career and leadership development skills, and the experiences of URM faculty Participant-led forums on navigating a career in academic medicine as a URM faculty member Individual career coaching to identify resources and mentors, successfully negotiate challenges, and achieve identified goals Applications accepted April 2nd – 30th, 2018 *NIH defines URM: Blacks or African Americans, Hispanics or Latinos, American Indians/Alaska Natives, Native Hawaiians and other Pacific Islanders

Services provided 24/7 Interdisciplinary consultation for pulmonary embolism Urgent/emergent for intermediate/high risk patients Facilitate urgent/emergent thrombolysis or interventional procedures as needed Ongoing consultation in-hospital Outpatient follow-up Educational resources Box.com library of resources including algorithms, papers. Quality and outcomes Institutional registry of outcomes

HOW TO CONTACT? PAGE P-E-R-T ! (7378)

MANAGEMENT ALGORITHM FOR PRIMARY TEAM PROVIDERS

Fellows’ Activation protocol

MANAGEMENT ALGORITHM FOR PERT PROVIDERS

Activations to date MRN RISK INTERVENTION DISPO 2827534 HIGH Lysis MICU 548021 INTER heparin IMCU 4231685 IVC filter 4227706 SICU 4227618 CCU 2872500 2249354 CDT 3815414 LOW 2712354 4232791 4173138 died before testing 3536187 3710255 4239321 Lysis at OSH

Multidisciplinary Training Program (T32) in Cardiovascular Epidemiology Vanessa Xanthakis, PhD Assistant Professor in Medicine and Biostatistics Section of Preventive Medicine and Epidemiology

Background Explosion of genetic and genomic data Biomarkers, metabolomics, proteomics - multidimensional Emergence of systems biology Collaborative research networks …major scientific advances? Biostatisticians trained to use advanced computational methods for modeling complex systems continues to be low The cardiovascular epidemiologist of this millennium must be trained in transdisciplinary knowledge Whole genome information, novel biomarkers, metabolomics, proteomics, vascular stiffness, echocardiography…serial measurements cohorts, disease, RFs..

Description 5-year NHLBI award PI: Ramachandran S. Vasan Focus is cardiovascular epidemiology training 5 trainees (MD or PhD), diverse backgrounds 20% URM 2-year training period To enable trainees to transition to independence, faculty status, or a first job

Innovative Aspects of the T32 Program

Innovative Aspects of the T32 Program Peer mentoring FHS Pathway Internal Medicine Residents T32 Trainees Mentors experts on subclinical CVD, translational genomics projects FHS Fellows

Key Elements and Skill Sets 1. Mentored Research and Progress Track-specific research project Introduction to research databases Work-In-Progress presentations Abstract submission/conference attendance Manuscript writing Career development award

Key Elements and Skill Sets 2. Multidisciplinary Curriculum Track-specific curriculum Cardiovascular Epidemiology course GMS/SPH/CTSI Master’s Degree in Clinical Investigation

Key Elements and Skill Sets 3. Research Seminars and Workshops FHS Conference Series in Cardiovascular Epidemiology Statistical Genetics Seminar Series at BUSPH Biostatistics Department Genome Science Institute Seminar Series GIM Seminar Series Bioinformatics Seminar Series Grant Writing Workshop

Key Elements and Skill Sets 4. Career Development Individual career mentoring myIDP One-on-one counseling service (OPDPA) Professional development (seminars and career planning sessions) Explore career pathways outside academia

Completing the training period Multidisciplinary scientific investigation Oral and written communication Personal interactions and networking Career planning and professional development Scientific responsibility

Current trainees Applicant Education Major Track Justin Echouffo University of Cambridge, PhD University of Cambridge, MPhil University of Yaoundé I, MD Epidemiology Medicine Translational Epidemiology Sarah Mazzilli University of New York at Buffalo Roswell Park Cancer Institute, PhD University of New York at Buffalo Roswell Park Cancer Institute, MS Molecular Pharmacology and Cancer Therapeutics Bioinformatics-Computational Biology Mekala Raman Mayo Clinic Graduate School of Biomedical Sciences, PhD Neurobiology of Diseases Todd Sponholtz Boston University School of Public Health, PhD Boston University School of Public Health, MPH Harvard University, MA Epidemiology & Biostatistics Biology Emilie Zoltick Harvard T.H. Chan School of Public Health, ScD Boston University School of Public Health, MPH Genetics-Genomics

T32 research focus of trainees Justin Echouffo: obesity sub-phenotypes, correlates and prognosis of cortisol level Sarah Mazzilli: gene expression similarities human/mouse bronchial premalignant lesions and COPD Mekala Raman: insulin-like growth factor and MRI phenotypes implicated in brain aging Todd Sponholtz: social, built environments in relation to subclinical CVD Emilie Zoltick: results of genome sequencing healthy adults

Total Number of Publications Total Number of Citations h-index Mean RCR Weighted RCR Echouffo, Justin 90 1131 19 1.56 109.03 Mazzilli, Sarah 8 21 3 4.68 Raman, Mekala 129 4 1.9 11.41 Sponholtz, Todd 10 76 0.66 3.94 Zoltick, Emilie 6 39 0.92 Total (Cohort) 138 1444 20 1.51 129.98 h-Index: Tracks the intersection of productivity and impact (ex: h-Index = 19 means 19 written papers which have been cited at least 19 times) RCR, (Relative Citation Ratio): Using the NIH’s iCite tool, looks at how many times an article funded by the NIH has been cited over a period of time as compared to similar peer publications. The expected number of citations is 1.00, so anything above 1.00 is significant. The weighted RCR is the sum for all articles in a group, in this case by author (or cohort). Expected number is the number of publications, so a weighted RCR of 129.98 for cohort with 108 as total number of publications is also significant.

Awards Justin Echouffo Scott Grundy Award for Excellence in Metabolism Research EPI/Lifestyle Scientific Sessions March 2018, New Orleans Todd Sponholtz NHLBI Cardiovascular, Epidemiology, Biostatistics, and Prevention Special Trainee Session EPI/Lifestyle Scientific Sessions March 2018, New Orleans

Next Group of Trainees Olga Cecilia Castro Diehl, MD DrPH MPH Epidemiology Maura Walker, MS PhD Biochemical and Molecular Nutrition Richard (Taylor) Pickering, PhD Nutrition and Metabolism Joowon Lee, MS PhD Exercise Physiology, Epidemiology and Biostatistics Laura E. Corlin, MS PhD Civil and Environmental Engineering, Environmental Health

Opportunities for faculty mentors Check out our T32 website!!!

Thank you!