Fusion of a Novel Gene, BTL, to ETV6 in Acute Myeloid Leukemias With a t(4;12)(q11-q12;p13)‏ by Jan Cools, Chrystèle Bilhou-Nabera, Iwona Wlodarska, Christine.

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Fusion of a Novel Gene, BTL, to ETV6 in Acute Myeloid Leukemias With a t(4;12)(q11-q12;p13)‏ by Jan Cools, Chrystèle Bilhou-Nabera, Iwona Wlodarska, Christine Cabrol, Pascaline Talmant, Philippe Bernard, Anne Hagemeijer, and Peter Marynen Blood Volume 94(5):1820-1824 September 1, 1999 ©1999 by American Society of Hematology

RT-PCR and schematic representation of the results. RT-PCR and schematic representation of the results. (A) Genomic structure of BTL and ETV6. The position of the PAC clones covering BTL was determined by Southern hybridization using oligonucleotides derived from the exon sequences (•, positive by hybridization; ○, negative by hybridization). The genomic structure of ETV6 was taken from Baens et al.12 The different primers used for PCR are shown in italics above the respective genomic structures. Exons are represented by gray boxes. E, EcoRI; H, HindIII. (B) Detection of the BTL-ETV6 and ETV6-BTL transcripts in the 4 cases by RT-PCR. Only the results of the second-round PCR are shown. nc, negative control. (C) Schematic representation of the predicted fusion proteins. Sequences derived from ETV6 are drawn in italics. Arrowheads mark the bounderies between the ETV6 and BTL parts. HR, hydrophobic region of BTL; HLH, helix-loop-helix domain of ETV6; ETS, DNA binding domain of ETV6. Jan Cools et al. Blood 1999;94:1820-1824 ©1999 by American Society of Hematology