Liver Cancer Checks in When Bile Acid Clocks Out

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Liver Cancer Checks in When Bile Acid Clocks Out Ting Fu, Xuan Zhao, Ronald M. Evans Cancer Cell Volume 30, Issue 6, Pages 827-828 (December 2016) DOI: 10.1016/j.ccell.2016.11.012 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Induction of HCC by Chronic Jet Lag Results from Global Gene Dysregulation Mediated through FXR and CAR Disruption of the peripheral clock by chronic jet lag leads to a sequential progression from NAFLD to NASH, cirrhosis, and ultimately HCC due to global metabolic dysfunction and gene dysregulation mediated through FXR and CAR. Cancer Cell 2016 30, 827-828DOI: (10.1016/j.ccell.2016.11.012) Copyright © 2016 Elsevier Inc. Terms and Conditions