11/7/2018 OSTEOPOROSIS.

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Presentation transcript:

11/7/2018 OSTEOPOROSIS

Treatment of Osteoporosis One injection of Zoledronic Acid a year ? 11/7/2018 OSTEOPOROSIS

Volume 346:653-661 Feb 28, 2002 Number 9 Intravenous Zoledronic Acid in Postmenopausal Women with Low Bone Mineral Density Ian R. Reid et al Zoledronic acid infusions given at intervals of up to one year produce effects on bone turnover and bone density as great as those achieved with daily oral dosing with bisphosphonates with proven efficacy against fractures, suggesting that an annual infusion of zoledronic acid might be an effective treatment for postmenopausal osteoporosis. 11/7/2018 OSTEOPOROSIS

… a therapeutic vaccine against the OPG-L Oct 2001 - ASBMR … a therapeutic vaccine against the OPG-L … could prevent / treat diseases associated with increased osteoclast activity and bone loss 11/7/2018 OSTEOPOROSIS

Cholesterol drugs may protect bones About half of women over 50 have a fracture because of osteoporosis sometime during their lives. Cholesterol drugs may protect bones Statins could offer women an alternative to hormone replacement therapy June 22 — Drugs commonly used to lower cholesterol could also help prevent bone fractures and osteoporosis in older women, offering an alternative to hormone replacement therapy, researchers said. MSNBC NEWS SERVICES 11/7/2018 OSTEOPOROSIS

Effects of Simvastatin on murine calvaria in vitro Statins Stimulate Bone Formation Effects of Simvastatin on murine calvaria in vitro Mundy G. et al Stimulation of bone formation in vitro and in rodents by statins Science. 286(5446):1946-9, 1999 Dec 3. 11/7/2018 OSTEOPOROSIS

How these two worlds came together Bisphosphonates and Statins How these two worlds came together 11/7/2018 OSTEOPOROSIS

Bisphosphonates and Statins Mevalonate pathway use a common pathway: the Mevalonate pathway 11/7/2018 OSTEOPOROSIS

The Mevalonate pathway 11/7/2018 OSTEOPOROSIS