DNA REPLICATION Preparing for Mitosis.

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Presentation transcript:

DNA REPLICATION Preparing for Mitosis

DNA REPLICATION DNA IS COPIED 1. DURING S-phase of INTERPHASE PREPARATION FOR CELL DIVISION

SEPARATION 2. THE STrAND OF DNA IS UNZIPPED BY HELICASE 3. THE POINT OF SEPARATION IS CALLED THE REPLICATION FORK

PREPARATION 4. The second enzyme, Primase, primes the dna for replication. 5. These partial sections are called Okazaki fragments.

NUCLEOTIDES ADDED 6. DNA POLYMERASE MOVE ALONG THE OPEN CHAINS AND MAKE NEW CHAINS WITH COMPLEMENTARY NUCLEOTIDES

FINALIZING THE NEW STRANDS 7. The final enzyme, Ligase, “lags” behind and reforms the phosphate & Sugar backbone

TWO STRANDS 8. NOW THERE ARE TWO STRANDS EACH STRAND HAS HALF OF THE ORIGINAL STRAND 9. EACH Daughter STRAND IS IDENTICAL TO THE ORIGINAL STRAND

Unzipped by: Helicase

Unzipped by: Helicase Primed by: Primase Unzipped by: Helicase New base pairs added by: DNA Polymerase Primed by: Primase

` Unzipped by: Helicase New base pairs added by: DNA Polymerase Unzipped by: Helicase ` New base pairs added by: DNA Polymerase Primed by: Primase Finalized by: Ligase

Optional MOVIES http://www.johnkyrk.com/DNAreplication.html http://www.pbs.org/wgbh/aso/tryit/dna/# http://www.ncc.gmu.edu/dna/repanim.htm http://www.hhmi.org/biointeractive/dna-replication-basic-detail