A Common Clinical Challenge: Neonatal Jaundice Is it Physiologic or Pathologic?

Slides:



Advertisements
Similar presentations
DIAGNOSTIC ANCILLARY PROCEDURES AND FINDINGS
Advertisements

Neonatal Jaundice Dezhi Mu MD/PhD
Case Report DISIDA Scan. Case I Name: 劉亦承 Age: 2 m/o Sex: Male.
Neonatal Jaundice By Dr. Nahed Al-Nagger
1 CLINICAL CHEMISTRY-2 (MLT 302) LIVER FUNCTION AND THE BILIARY TRACT LECTURE FOUR Dr. Essam H. Aljiffri.
1 CLINICAL CHEMISTRY-2 (MLT 302) LIVER FUNCTION AND THE BILIARY TRACT LECTURE THREE Dr. Essam H. Aljiffri.
JAUNDICE JAUNDICE By:DR/FATMA AL-THOUBAITY Surgical Consultant Assisstant Professor.
The Neonatal Period. Be able to define the neonatal period Know how and when jaundice can present and when to initiate treatment Be able to recognise.
Chapter 15 Bilirubin and Urobilinogen
CHOLEDOCHAL CYSTS Aswad Habeeb Hameed Al-Obeidy FICMS GE & Hep.
FATIMA DARAKHSHAN (2K10-BS-V&I-35)
Primary Sclerosing Cholangitis
Clinical Approach to Neonatal Jaundice
Dr.Abdulaziz Alsoumali Intern Alyamamh hospital Pediatric rotation
Quality Education for a Healthier Scotland Multidisciplinary Neonatal Jaundice Promoting multiprofessional education and development in Scottish maternity.
Skin disorder: -Treatment of pre-existing skin disorders, such as eczema or psoriasis, - topical agents should be used with caution in pregnancy (such.
Liver Seminar for Health Plan Case Managers September 23, 2008 October 2, 2008.
Neonatal Jaundice 新生兒黃疸. History 病人是自然產出生一天大的男嬰;母親 是 24 歲 G2P1A1 客家人,產前實驗室檢 查正常,懷孕過程順利, group B streptococcus 檢查是陰性,母親血型是 O positive ,破水時間是 1 小時。男嬰出 生體重是.
PRACTICE TEACHING ON THALASSEMIA. INTRODUCTION O Inherited blood disorder O an abnormal form of hemoglobin due to a defect through a genetic mutation.
Hemophilia in Canis familiaris (dogs). General information MIM number: MIM number: MIA number: MIA number:
Topic Review Biliary atresia Division of gastroenterology Department of pediatric YUMC R3 허윤정.
Development Aspects of Blood Anatomy and Physiology.
Liver and biliary tract disorders. Synthesis of plasma proteins Albumin, prealbumin, transferin, coagulations factors…. Detoxication reactions of endogen.
Pediatric Cholestatic Jaundice: Differential Diagnosis of Treatable Disorders Saul J. Karpen, MD, PhD Professor of Pediatrics Raymond F. Schinazi Distinguished.
Upfront Combination Therapy vs Step-Up Approach for PAH:
The “H-response” is a prominent photic driving response at flash rates beyond 20 Hz. In a critical review of the literature, the reported sensitivity of.
Biomedical Therapies Foundation Standard 1: Academic Foundation
Diagnosis, Prognosis, and Management of aHUS
Lysosomal Acid Lipase Deficiency: Paving the Path for an Early Diagnosis.
Duration of Dual Antiplatelet Therapy Post-ACS: Lessons From Clinical Trials.
Why Gene Therapy for Hemophilia?
Chronic Hepatitis C Virus Infection
Starting Strong: Initial Evaluation of the Patient With HCV
MR Imaging in Children.
Diagnosing Rheumatoid Arthritis Early
Merkel Cell Carcinoma: What Do Clinicians Need to Know?
Ask the Onychomycosis Expert, Part 2
Seasonal Allergic Rhinitis
When Minutes Count.
Hunter Syndrome: Why We Need to Diagnose and Treat Early
Duration of Dual Antiplatelet Therapy Post-ACS: Lessons from Clinical Trials.
Early Dementia Distinguishing AD From MCI
Updates in Management of Atopic Dermatitis From Real Patient Cases
Advances in Dry Eye.
A Closer Look at Pemphigus Vulgaris: Clinical Challenges and Emerging Treatments.
Managing IBD in Children
Chronic Idiopathic Urticaria
Tailoring Hemophilia Prophylaxis Therapy
GLP-1 Receptor Agonists: How Early Is Appropriate?
Asthma and Atopic Comorbidities
Program Overview. Major Depressive Disorder: The Challenging Patient and the Goal of Recovery.
Current and Emerging Strategies for Management of Moderate-to-Severe Atopic Dermatitis.
Combining Efforts for Older Drivers: Licensing Agencies, Occupational Therapists, and Clinicians.
Duration of Dual Antiplatelet Therapy Post-ACS: Lessons from Clinical Trials.
Moving the Goal Post: Multidisciplinary Management of Advanced NSCLC
Lysosomal Acid Lipase Deficiency: Paving the Path for an Early Diagnosis.
Lysosomal Acid Lipase Deficiency: Paving the Path for an Early Diagnosis.
This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States, and data.
Treating Atypical Hemolytic Uremic Syndrome A Case Discussion
The Patient With Early Stage MF-CTCL
New Clinical Insights Into the Pathology of Amyloidosis
The Role of Measurable Residual Disease in AML
Disease Burden of VTE Phases of VTE Treatment.

Importance of Early Diagnosis and Management in SMA
A Child with Jaundice M Rawashdeh, MD, MSc, FRCP, FRCPCH
Merging the Art and Science of Managing nOH in Clinical Practice
The Building Blocks of Homocystinuria and Homocysteinemia Management
Next-Generation Sequencing and ctDNA
Exploring the Use of Adeno-Associated Virus for Gene Therapy
Presentation transcript:

Pediatric Cholestatic Jaundice: Differential Diagnosis of Treatable Disorders

A Common Clinical Challenge: Neonatal Jaundice Is it Physiologic or Pathologic?

Case: Full-Term Female Infant

Neonatal Jaundice

Neonatal Jaundice (cont)

Case (cont) Recurrence of Jaundice After Initial Improvement

Case (cont) Diagnosis: Prolonged Neonatal Jaundice

Prolonged Neonatal Jaundice Breast Milk-Related Jaundice

Prolonged Neonatal Jaundice: Is It Noncholestatic or Cholestatic in Origin?

Liver Disease in the Newborn

Differential Diagnosis of Cholestasis in Newborns Think Anatomic

Differential Diagnosis of Cholestasis in Newborns (cont)

Evaluating Prolonged Neonatal Jaundice Visual Assessment is Observer Dependent

NASPGHAN/ESPGHAN: Recommendations for Evaluation of the Potential for Cholestatic Liver Diseases

Evaluation of the Baby With Persistent Jaundice

Evaluation of the Baby With Persistent Jaundice (cont)

Physical Examination of the Baby With Persistent Jaundice: Head to Toe

Physical Examination of the Baby With Persistent Jaundice: Head to Toe (cont)

Evaluation of the Baby With Persistent Jaundice Additional Laboratory Tests

Evaluation of the Baby With Persistent Jaundice Additional Laboratory Tests (cont)

Differential Diagnosis: Intrahepatic Cholestasis Red Flags That Require Early Intervention

Differential Diagnosis of Treatable Disorders: Single-Gene Defects Identification and Early Intervention Can Make a Difference

Origins of Neonatal Cholestasis

Emory Cholestasis 57 Gene Panel Emory Cholestasis 57 Gene Panel* Only 1 Blood Sample Required to Identify Key Genes: Example of a Gene Panel

NASPGHAN/ESPGHAN Recommendations

NASPGHAN/ESPGHAN Recommendations (cont)

NASPGHAN/ESPGHAN Recommendations (cont)

NASPGHAN/ESPGHAN Recommendation Consider Whether a Liver Biopsy Would Be Helpful

Liver Biopsy for Biliary Atresia Does the Patient Need An Intraoperative Cholangiogram?

Biliary Atresia

Therapies Are Available for Some Cholestatic Disorders

Concluding Remarks Take-Home Messages

Abbreviations

Abbreviations (cont)