Pediatric Cholestatic Jaundice: Differential Diagnosis of Treatable Disorders
A Common Clinical Challenge: Neonatal Jaundice Is it Physiologic or Pathologic?
Case: Full-Term Female Infant
Neonatal Jaundice
Neonatal Jaundice (cont)
Case (cont) Recurrence of Jaundice After Initial Improvement
Case (cont) Diagnosis: Prolonged Neonatal Jaundice
Prolonged Neonatal Jaundice Breast Milk-Related Jaundice
Prolonged Neonatal Jaundice: Is It Noncholestatic or Cholestatic in Origin?
Liver Disease in the Newborn
Differential Diagnosis of Cholestasis in Newborns Think Anatomic
Differential Diagnosis of Cholestasis in Newborns (cont)
Evaluating Prolonged Neonatal Jaundice Visual Assessment is Observer Dependent
NASPGHAN/ESPGHAN: Recommendations for Evaluation of the Potential for Cholestatic Liver Diseases
Evaluation of the Baby With Persistent Jaundice
Evaluation of the Baby With Persistent Jaundice (cont)
Physical Examination of the Baby With Persistent Jaundice: Head to Toe
Physical Examination of the Baby With Persistent Jaundice: Head to Toe (cont)
Evaluation of the Baby With Persistent Jaundice Additional Laboratory Tests
Evaluation of the Baby With Persistent Jaundice Additional Laboratory Tests (cont)
Differential Diagnosis: Intrahepatic Cholestasis Red Flags That Require Early Intervention
Differential Diagnosis of Treatable Disorders: Single-Gene Defects Identification and Early Intervention Can Make a Difference
Origins of Neonatal Cholestasis
Emory Cholestasis 57 Gene Panel Emory Cholestasis 57 Gene Panel* Only 1 Blood Sample Required to Identify Key Genes: Example of a Gene Panel
NASPGHAN/ESPGHAN Recommendations
NASPGHAN/ESPGHAN Recommendations (cont)
NASPGHAN/ESPGHAN Recommendations (cont)
NASPGHAN/ESPGHAN Recommendation Consider Whether a Liver Biopsy Would Be Helpful
Liver Biopsy for Biliary Atresia Does the Patient Need An Intraoperative Cholangiogram?
Biliary Atresia
Therapies Are Available for Some Cholestatic Disorders
Concluding Remarks Take-Home Messages
Abbreviations
Abbreviations (cont)