Dose/Response Relationship Dose - the amount of a chemical/substance that is administered to an experimental animal Dosage - dose specified with relation to a characteristic of the animal like weight or skin area

Dose/Response Relationship Response - specific adverse health effects observed ex. death, tumor growth, organ impairment there may actually be several responses but only one is examined at a time Use this data to create a dose/response curve

Dose-response curves 8-14 Figure 8.16 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Dose-response curves Figure 8.16 8-14

Toxicity and LD50 8-12 Figure 8.15 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Toxicity and LD50 Figure 8.15 8-12

Curve Forms Linear curve no threshold Linear curve w/threshold Stochastic response Linear curve w/threshold Deterministic response Non-Linear curve w/ or w/o threshold

Epidemiology the study of the occurrence of adverse health effects in humans search for patterns of exposure to chemicals, radiation, or even patterns of diet relate these patterns to to incidence of disease, damage or impairment Concerned with GROUPS not individuals