“Toll”-erance in the Skin

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“Toll”-erance in the Skin Tina L. Sumpter, Louis D. Falo Immunity Volume 41, Issue 5, Pages 677-679 (November 2014) DOI: 10.1016/j.immuni.2014.11.003 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 S. aureus Recruits MDSCs to the Skin Interactions between S. aureus and TLR2/6 heterodimers on keratinocytes cause release of IL-6, CCL22, and CCL28. These factors expand and recruit MDSCs to the skin. MDSCs in turn suppress T cell expansion via a NO-dependent mechanism. Immunity 2014 41, 677-679DOI: (10.1016/j.immuni.2014.11.003) Copyright © 2014 Elsevier Inc. Terms and Conditions