Skin Explant Model of Human Graft-versus-Host Disease: Prediction of Clinical Outcome and Correlation with Biological Risk Factors Xiao-nong Wang, Matthew.

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Presentation transcript:

Skin Explant Model of Human Graft-versus-Host Disease: Prediction of Clinical Outcome and Correlation with Biological Risk Factors Xiao-nong Wang, Matthew Collin, Lisbet Sviland, Scott Marshall, Graham Jackson, Ute Schulz, Ernst Holler, Sigrid Karrer, Hildegard Greinix, Fariborz Elahi, Ilona Hromadnikova, A.M. Dickinson Biology of Blood and Marrow Transplantation Volume 12, Issue 2, Pages 152-159 (February 2006) DOI: 10.1016/j.bbmt.2005.09.018 Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Histopathologic changes for different grades of skin GVHR. A, Grade I skin GVHR showing very mild vacuolization of epidermal cells. B, Grade II skin GVHR showing diffuse vacuolization of epidermal cells. C, Grade III skin GVHR showing cleft formation between the epidermis and dermis caused by confluent vacuolar damage to basal keratinocytes. D, Grade IV skin GVHR showing the complete separation of the epidermis and dermis. Biology of Blood and Marrow Transplantation 2006 12, 152-159DOI: (10.1016/j.bbmt.2005.09.018) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Association of skin GVHR grade with HLA matching status, sex combinations, and patient age. In Figure 2A, a, b, and c represent HLA-matched related, HLA-matched unrelated, and HLA-unmatched unrelated allopairs, respectively. Biology of Blood and Marrow Transplantation 2006 12, 152-159DOI: (10.1016/j.bbmt.2005.09.018) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions