CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation.

Slides:

Advertisements

Similar presentations

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD by Ana C. Alho, Haesook T.

Advertisements

Kazunori Kanehira, Douglas L. Riegert-Johnson, Dong Chen, Lawrence E

a b c Figure S1 Figure S1: Gating strategy describing T cell subsets.

Clinical “cytokine storm” as revealed by monocyte intracellular flow cytometry: correlation of tumor necrosis factor α with severe gut graft-versus-host.

CXCR6 and CCR5 Localize T Lymphocyte Subsets in Nasopharyngeal Carcinoma Greg Parsonage, Lee Richard Machado, Jan Wai-Ying Hui, Andrew McLarnon, Tilo.

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.

WT1-specific T-cell responses in high-risk multiple myeloma patients undergoing allogeneic T cell–depleted hematopoietic stem cell transplantation and.

Increase in FOXP3+ Regulatory T Cells in GVHD Skin Biopsies Is Associated with Lower Disease Severity and Treatment Response Cristina Fondi, Chiara Nozzoli,

In Situ Detection of HY-Specific T Cells in Acute Graft-versus-Host Disease–Affected Male Skin after Sex-Mismatched Stem Cell Transplantation Yeung-Hyen.

Frequency of CD4+CD25hiFOXP3+ Regulatory T Cells Has Diagnostic and Prognostic Value as a Biomarker for Acute Graft-versus-Host-Disease John M. Magenau,

Increased Plasma Indoleamine 2,3-Dioxygenase Activity and Interferon-γ Levels Correlate with the Severity of Acute Graft-versus-Host Disease after Allogeneic.

Monocyte chemoattractant chemokines in cystic fibrosis

Anti-CD20 monoclonal antibody treatment in 6 patients with therapy-refractory chronic graft-versus-host disease by Marijke R. Canninga-van Dijk, Hanneke.

Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation

CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood by Mohamed F. Elshal,

Successful Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplant in an Acute Leukemia Patient With Chemotherapy-Induced Marrow Aplasia and Progressive.

Nonmyeloablative conditioning for relapsed follicular lymphoma

Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma by Kristoph Jahnke, Sarah E. Coupland, Il-Kang.

Immune Reconstitution after Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation

SOX11 holds mantle cell lymphoma’s key to home

by Yoshinobu Maeda, Pavan Reddy, Kathleen P

Frequent Detection of Herpes Simplex Virus Antigen in Skin and Peripheral Blood CD34+ Mononuclear Cells from Patients with Graft-versus-Host Disease

Volume 67, Issue 4, Pages (April 2005)

Loss of T Follicular Helper Cells in the Peripheral Blood of Patients with Chronic Graft- versus-Host Disease David A. Knorr, Hongbo Wang, Mukta Aurora,

Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets.

Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma by Marion Lambert, Monique.

Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.

Altered Homeostasis of CD4+ Memory T Cells in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Chronic Graft-versus-Host Disease Enhances T Cell.

CXCR3-Mediated Skin Homing of Autoreactive CD8 T Cells Is a Key Determinant in Murine Graft-Versus-Host Disease Vadim A. Villarroel, Naoko Okiyama, Gaku.

by Jayesh Mehta Blood Volume 112(2): July 15, 2008

Kazunori Kanehira, Douglas L. Riegert-Johnson, Dong Chen, Lawrence E

Mark A. Schroeder, Jaebok Choi, Karl Staser, John F. DiPersio

PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model) Yehudith Azar, Reut.

Fatal Hyperacute Graft-versus-Host Disease following Denileukin Diftitox Treatment for Recurrent T Cell Lymphoma after Allogeneic Stem Cell Transplantation

Clinical “cytokine storm” as revealed by monocyte intracellular flow cytometry: correlation of tumor necrosis factor α with severe gut graft-versus-host.

Activation and Expansion of CD8+ T Effector Cells in Patients with Chronic Graft- versus-Host Disease Bryan M. Grogan, Laura Tabellini, Barry Storer,

Unique Abnormalities of CD4+ and CD8+ Central Memory Cells Associated with Chronic Graft-versus-Host Disease Improve after Extracorporeal Photopheresis

Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine,

Spontaneous Autologous Graft-versus-Host Disease in Plasma Cell Myeloma Autograft Recipients: Flow Cytometric Analysis of Hematopoietic Progenitor Cell.

Chimerism studies in HLA-identical nonmyeloablative hematopoietic stem cell transplantation point to the donor CD8+ T-cell count on day +14 as a predictor.

Volume 147, Issue 1, Pages e7 (July 2014)

Up-Regulation of α4β7 Integrin on Peripheral T Cell Subsets Correlates with the Development of Acute Intestinal Graft-versus-Host Disease following Allogeneic.

Immunopathologic Features of Allergic Contact Dermatitis in Humans: Participation of Plasmacytoid Dendritic Cells in the Pathogenesis of the Disease?

Chemokine-mediated tissue recruitment of CXCR3+ CD4+ T cells plays a major role in the pathogenesis of chronic GVHD by Joanne E. Croudace, Charlotte F.

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease by Tangsheng Yi, Dongchang Zhao, Chia-Lei.

Keratinocyte-Derived Chemokines Orchestrate T-Cell Positioning in the Epidermis during Vitiligo and May Serve as Biomarkers of Disease Jillian M. Richmond,

CD161+ T Cells as Predictive Markers for Acute Graft-versus-Host Disease Sung-Eun Lee, Ji-Young Lim, Jae-Ho Yoon, Seung-Hwan Shin, Byung-Sik Cho, Ki-Seong.

Sequential Expression of Adhesion and Costimulatory Molecules in Graft-versus-Host Disease Target Organs after Murine Bone Marrow Transplantation across.

Increased Programmed Death-1 Molecule Expression in Cytomegalovirus Disease and Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation

Lisa A. Palmer, George E. Sale, John I

Haploidentical Transplantation Using T Cell Replete Peripheral Blood Stem Cells and Myeloablative Conditioning in Patients with High-Risk Hematologic.

Increased, but Functionally Impaired, CD14+ HLA-DR–/low Myeloid-Derived Suppressor Cells in Psoriasis: A Mechanism of Dysregulated T Cells David C. Soler,

The Expression of Th17-Associated Cytokines in Human Acute Graft-versus-Host Disease Yuejun Liu, Yifeng Cai, Lan Dai, Guanghua Chen, Xiao Ma, Ying Wang,

Benjamin T. Prince, MD, Msci, Ashley L. Devonshire, MD, MPH, Kristin A

Prevention of Graft-versus-Host Disease by Adoptive T Regulatory Therapy Is Associated with Active Repression of Peripheral Blood Toll-Like Receptor 5.

Epidermal Elafin Expression Is an Indicator of Poor Prognosis in Cutaneous Graft- versus-Host Disease Marie-Charlotte Brüggen, Peter Petzelbauer, Hildegard.

Human TCM have potent effector functions, home to skin, and induce dermatitis in human engrafted mice. Human TCMhave potent effector functions, home to.

A Novel Soluble Form of Tim-3 Associated with Severe Graft-versus-Host Disease John A. Hansen, Samir M. Hanash, Laura Tabellini, Chris Baik, Richard L.

Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease by Jennifer S. Whangbo, Haesook.

Chronic GVHD and Pretransplantation Abnormalities in Pulmonary Function Are the Main Determinants Predicting Worsening Pulmonary Function in Long-term.

by Ahmed Gehad, Jessica E. Teague, Tiago R

Figure 1 BG-12 treatment reduced total circulating B cells and had variable effects on memory B cells BG-12 treatment reduced total circulating B cells.

Low Serum Levels of Total Rabbit-IgG Is Associated with Acute Graft-Versus-Host Disease after Unrelated Donor Hematopoietic Stem Cell Transplantation:

Plasmacytoid Dendritic Cells: A New Cutaneous Dendritic Cell Subset with Distinct Role in Inflammatory Skin Diseases Andreas Wollenberg, Sandra Günther,

Yuri Fedoriw, T. Danielle Samulski, Allison M. Deal, Cherie H

Prospective Monitoring of Tumor Necrosis Factor α and Interferon γ to Predict the Onset of Acute and Chronic Graft-versus-Host Disease after Allogeneic.

Outcomes among Patients with Recurrent High-Risk Hematologic Malignancies after Allogeneic Hematopoietic Cell Transplantation Marco Mielcarek, Barry.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Graft Monocytic Myeloid-Derived Suppressor Cell Content Predicts the Risk of Acute Graft-versus-Host Disease after Allogeneic Transplantation of Granulocyte.

Frequency of CD4+CD25hiFOXP3+ Regulatory T Cells Has Diagnostic and Prognostic Value as a Biomarker for Acute Graft-versus-Host-Disease John M. Magenau,

Presentation transcript:

CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation by Karen P. Piper, Claire Horlock, S. John Curnow, Julie Arrazi, Sarah Nicholls, Premini Mahendra, Charles Craddock, and Paul A. H. Moss Blood Volume 110(12):3827-3832 December 1, 2007 ©2007 by American Society of Hematology

The kinetics of serum chemokine levels in SCT patients with and without GVHD. (A) CCL5 and (B) CXCL10 levels in patients with (—) or without (- - -) aGVHD. The kinetics of serum chemokine levels in SCT patients with and without GVHD. (A) CCL5 and (B) CXCL10 levels in patients with (—) or without (- - -) aGVHD. Data presented as means plus SE bars. Karen P. Piper et al. Blood 2007;110:3827-3832 ©2007 by American Society of Hematology

Comparison of cytokine and chemokine levels between myeloablative and nonmyeloablative SCT patients with and without GVHD. Patients with and without GVHD were subdivided into those who underwent myeloablative transplantation and those who underwent nonmyelo... Comparison of cytokine and chemokine levels between myeloablative and nonmyeloablative SCT patients with and without GVHD. Patients with and without GVHD were subdivided into those who underwent myeloablative transplantation and those who underwent nonmyeloablative transplantation. Solid lines represent median markers. P values were calculated using the Mann-Whitney U test (*P < .05; **P < .01). Karen P. Piper et al. Blood 2007;110:3827-3832 ©2007 by American Society of Hematology

CXCR3 expression on naive, memory, and regulatory T-cell subsets from SCT patients with and without GVHD. CXCR3 expression on naive (CCR7+CD45RA+), central memory (CCR7+CD45RA−), effector memory (CCR7−CD45RA−), and effector memory revertant (CCR7−CD45RA+) C... CXCR3 expression on naive, memory, and regulatory T-cell subsets from SCT patients with and without GVHD. CXCR3 expression on naive (CCR7+CD45RA+), central memory (CCR7+CD45RA−), effector memory (CCR7−CD45RA−), and effector memory revertant (CCR7−CD45RA+) CD4+ (A) and CD8+ (B) T cells from SCT patients with GVHD (▨) and without GVHD (□). The y-axis represents the proportion of T cells positive for CXCR3. Bars represent median and range. (C) Regulatory T-cell numbers in PBMCs. PBMCs were gated on CD4+CD45RO+ T cells and T reg frequency was determined by their positive expression for CD25 and low expression for CD127. (D) CXCR3 expression on T reg cells. ▴ indicates SCT patients with GVHD; ▵ indicates control SCT patients without GVHD. The y-axis represents the number of cells positive for marker(s) per microliter of peripheral blood. Solid line represents the mean. Karen P. Piper et al. Blood 2007;110:3827-3832 ©2007 by American Society of Hematology

Expression of CXCL10 and CXCR3 in skin biopsies from patients with aGVHD and control patients. Expression of CXCL10 and CXCR3 in skin biopsies from patients with aGVHD and control patients. A representative example from 11 patients with GVHD and 5 control patients. Single enzymatic staining for CXCL10 (ligand; brown stain) showed significant expression of CXCL10 in basal keratinocytes of the epidermal (e) layer of aGVHD skin versus no expression on control tissue. CXCR3 expression (brown stain) was located to the dermal (d) infiltrates located in close proximity to the epidermis in aGVHD skin. Control tissue lacked these infiltrates but showed some CXCR3 expression on scattered T cells within the dermis. Arrows indicate positive staining. See “Immunohistochemistry” for complete image acquisition information. Karen P. Piper et al. Blood 2007;110:3827-3832 ©2007 by American Society of Hematology