Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy Arturo.

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Presentation transcript:

Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy Arturo R. Palomares, M.Sc., Ana M. Lendínez-Ramírez, M.Sc., Beatriz Pérez-Nevot, M.Sc., Miriam Cortés-Rodríguez, M.Sc., Francisco Martínez, Ph.D., Nicolás Garrido, Ph.D., Maximiliano Ruiz-Galdón, M.D., Armando Reyes-Engel, M.D. Fertility and Sterility Volume 99, Issue 7, Pages 2009-2016.e2 (June 2013) DOI: 10.1016/j.fertnstert.2013.02.026 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Hypothesized scheme representing serotonin (5-HT) interaction with different genes included in the study. Monoamine oxydase A (MAO-A) degrading activity of 5-HT would remove it in 5-hydroxyndolacetic acid (5-HIAA). Tryptophan can derive in 5-HT by tryptophan hydroxylase 1 (TPH1) and aromatic amino acid decarboxylase (AADC) enzymes. The 5-HT receptors 2A and 2C activate phospholipase C (PLC) through G-protein (Gq) coupled subunit that promotes transformation of phosphatidylinositol 4,5-bisphosphate (PIP2) in diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). These second messengers activate protein kinase C (PKC), which in time may activate the extracellular signal-regulated kinases (ERK). 5-HT1A G-protein (Gi) coupled subunit inhibits the formation of cyclic adenylate monophosphate (cAMP) by adenylate cyclase (AC), which also modify ERK activity in a different way. Fertility and Sterility 2013 99, 2009-2016.e2DOI: (10.1016/j.fertnstert.2013.02.026) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions