Humoral immune response

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Presentation transcript:

Humoral immune response B cells Humoral immune response

Antigen receptors on lymphocytes B cell T cell Antigens: proteins, polysaccharides, lipids, nucleic acids, small molecules Conformational and linear epitops Complex of peptide-MHC molecule on an APC Linear epitops

B cell maturation

B cell maturation

pro B

pre B receptor pro B

(Bruton’s tyrosine kinase) Active Btk enables: survival, proliferation and further maturation etc. Mutation of BTK gene: X-linked agammaglobulinemia (Bruton’s agammaglobulinemia) Btk (Bruton’s tyrosine kinase)

immature B IgM pre B receptor pro B

IgM IgD IgM pre B receptor mature B immature B pro B

12

IgD IgM MHC II CD40 B-7

Humoral immune response Thymus-dependent (T-dependent, TD) Thymus-independent (T-independent, TI)

Subsets of B cells

Phases of humoral immune response

(two-signal requirement) Activation of B cells (two-signal requirement)

(intracellular signaling) Activation of B cells (intracellular signaling)

Functional consequences of B cell activation

Functional consequences of B cell activation

Functions of antibody isotypes

Primary and secondary antibody response