Comparison of seizure reduction and serum fatty acid levels after receiving the ketogenic and modified Atkins diet  Natacha Porta, Louis Vallée, Elisabeth Boutry, Monique Fontaine, Anne-Frédérique Dessein, Sylvie Joriot, Jean-Marie Cuisset, Jean- Christophe Cuvellier, Stéphane Auvin  Seizure - European Journal of Epilepsy  Volume 18, Issue 5, Pages 359-364 (June 2009) DOI: 10.1016/j.seizure.2009.01.004 Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 1 Seizure reduction in patients remaining on KD and on modified Atkins diet at 1, 3, 6 and 12 months. Seizure - European Journal of Epilepsy 2009 18, 359-364DOI: (10.1016/j.seizure.2009.01.004) Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 2 Level of fatty acids in patient serum before and at 1, 3, 6 and 12 months after the initiation of the KD or the modified Atkins diet. (A) Saturated and monounsaturated fatty acids; (B) Polyunsaturated fatty acids. Start n=17, 1 month n=15; 3 months n=12; 6 months n=7; 12 months n=4. *p≤0.05 in comparison with start; ■, p=0.02 in comparison with 1 month. Myristic: myristic acid (C14:0); palmitic: palmitic acid (C16:0); palmitoleic: palmitoleic acid (C16:1); stearic: stearic acid (C18:0); oleic: oleic acid (C18:1); LA+ALA: linoleic acid (C18:2 n-6)+alpha-linolenic acid (C18:3 n-3); homo lino: homo linoleic acid (C20:3 n-6); EPA: eicosapentaenoic acid (C20:5 n-3); mead: eicosatrienoic (C20:3 n-9); AA: arachidonic acid (C20:4 n-6); DHA: docosahexaenoic acid (C22:6 n-3). Seizure - European Journal of Epilepsy 2009 18, 359-364DOI: (10.1016/j.seizure.2009.01.004) Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 3 Levels of fatty acids in responders and in non-responders 1 and 3 months after initiation of the KD and the modified Atkins diet. (A) Data after 1 month of treatment, non-responders (≤50%) n=7; responders (>50%) n=7. (B) Data after 3 months of treatment, non-responders (≤50%) n=6; responders (>50%) n=6. *p≤0.05 in comparison with non-responder group (≤50). Myristic: myristic acid (C14:0); palmitic: palmitic acid (C16:0); palmitoleic: palmitoleic acid (C16:1); stearic: stearic acid (C18:0); oleic: oleic acid (C18:1); LA+ALA: linoleic acid (C18:2 n-6)+alpha-linolenic acid (C18:3 n-3); homo lino: homo linoleic acid (C20:3 n-6); EPA: eicosapentaenoic acid (C20:5 n-3); mead: eicosatrienoic (C20:3 n-9); AA: arachidonic acid (C20:4 n-6); DHA: docosahexaenoic acid (C22:6 n-3). Seizure - European Journal of Epilepsy 2009 18, 359-364DOI: (10.1016/j.seizure.2009.01.004) Copyright © 2009 British Epilepsy Association Terms and Conditions