Disparities in CRC in Hispanics

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Presentation transcript:

Epidemiologic, Environmental & Molecular Disparities in GI Cancer Among Hispanics

Disparities in CRC in Hispanics

Cancer Health Disparities

Population Geographical Distributions by Race/Ethnicity

Colorectal Cancer (2012)

20 Highest Countries in the Americas

Age-Adjusted. Incidence Rates of Colorectal Cancer in U. S Age-Adjusted* Incidence Rates of Colorectal Cancer in U.S. by sex and Race/Ethnicity (2009-2013)

Age-Adjusted. Mortality Rates from Colorectal Cancer in U. S Age-Adjusted* Mortality Rates from Colorectal Cancer in U.S. by sex and Race/Ethnicity 2009-2013

CRC Incidence Increases for Hispanics when comparing rates in their Native country to US rates

5-Year Survivorship According to Age at Diagnosis in US Hispanics (2005-2010)

Disparities in CRC in Hispanics

Environment & Colorectal Carcinogenesis

Gut Microbiome & Colon Cancer

Phylogenic Differences in Gut Microbiome Composition between African Americans (AA) and North African (using 16S-rRNA)

Pro-inflammatory Environment with Lower SSF & Higher Bile Acids in African Americans

Gut Microbiome --- Colorectal Neoplasia

Role of Gut Bacterial Genes

Higher Prevalence of Genotoxic Bacterial Toxins in Stool of Patients with CRN

Disparities in CRC in Hispanics

Molecular Characterization of Colorectal Cancer in Hispanics

Molecular Characterization of CRC tumors of Puerto Rican Hispanics

Hereditary Contribution to CRC

GWAS Hits Hispanics Associated with CRC

GWAS Hits in Hispanics Associated with CRC

Ancestry Proportion Hispanics from PR and Colon CFR

Genetic ancestry and CRC risk in PRH

Nutrition, Genetic Ancestry and CRN risk in PRH

Summary Disparities

Picture of Screening

Prevalence of Colorectal Cancer Screening by Ethnicity in U. S Prevalence of Colorectal Cancer Screening by Ethnicity in U.S.* and PR, 2012

Administrative Order 334

International CRC Screening Programs International CRC Screening Network

Colon Cancer Dress in Blue Day March 4, 2016

www.coloncancerpr.org

GI GENE TEAM (Gastrointestinal Genetic Epidemiology Network)