Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma David G. Mummy, MS, Stanley J. Kruger,

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Presentation transcript:

Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma David G. Mummy, MS, Stanley J. Kruger, PhD, Wei Zha, PhD, Ronald L. Sorkness, PhD, Nizar N. Jarjour, MD, Mark L. Schiebler, MD, Loren C. Denlinger, MD, PhD, Michael D. Evans, MS, Sean B. Fain, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 3, Pages 1140-1141.e4 (March 2018) DOI: 10.1016/j.jaci.2017.10.016 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Whole lung VDP vs outcome group in subjects with asthma. VDP (median, interquartile range): No ED or hospitalization (HOSP), (0.78, 1.77); ED alone, (0.85, 2.95); HOSP, (4.0, 3.86). Shown above are typical images of hyperpolarized 3He MRI for subjects in corresponding outcome groups. Arrows indicate apparent ventilation defects. VDP for example images: no ED or HOSP, 0.97%; ED alone, 1.93%; HOSP, 6.53%. Journal of Allergy and Clinical Immunology 2018 141, 1140-1141.e4DOI: (10.1016/j.jaci.2017.10.016) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Gradient boosting machine results showing VDP with highest relative influence over other factors in predicting history of severe outcomes. EOS, Eosinophil; MAC, macrophage; PMN, neutrophil. Journal of Allergy and Clinical Immunology 2018 141, 1140-1141.e4DOI: (10.1016/j.jaci.2017.10.016) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Receiver-operating characteristic (ROC) curves illustrating assocations of selected biomarkers of obstruction with a history of ED visits and hospitalizations among subjects with asthma. EOS #, Eosinophil count. Journal of Allergy and Clinical Immunology 2018 141, 1140-1141.e4DOI: (10.1016/j.jaci.2017.10.016) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions