The Secrets of its Strength

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Presentation transcript:

The Secrets of its Strength Bone: The Secrets of its Strength Bone is Not Just Minerals It is a Mixture of Proteins and Minerals P a t h o p y s i l g 11/8/2018 OSTEOPOROSIS

Take a wall as an example h o p y s i l g You need cement to hold the stones together 11/8/2018 OSTEOPOROSIS

The cement for the bone is P a t h o p y s i l g The cement for the bone is collagen 11/8/2018 OSTEOPOROSIS

How the Bone Remains Strong P a t h o p y s i l g How the Bone Remains Strong Replacement of old bone with new one is the way nature preserves the strength of the bone 11/8/2018 OSTEOPOROSIS

Bone remodeling The Skeleton is ... Under Construction …from Birth ... P a t h o p y s i l g The Skeleton is ... Under Construction …from Birth ... Until Death 11/8/2018 OSTEOPOROSIS

Bone remodeling First … the Osteoclast digs holes into the bone P a t y s i l g First … the Osteoclast digs holes into the bone 11/8/2018 OSTEOPOROSIS

the Osteoblast follows …. …and then… P a t h o p y s i l g the Osteoblast follows …. ….to replace it with new bone 11/8/2018 OSTEOPOROSIS

Bone remodeling Osteoclast (resorbs bone) Replacement of old bone with new one is the way nature preserves the strength of the bone Osteoblast (builds bone) New bone 11/8/2018 OSTEOPOROSIS

Osteoporosis … too many Osteoclasts Pathophysiology Osteoporosis Osteoclast Osteoclast Osteoclast Osteoclast … too many Osteoclasts 11/8/2018 OSTEOPOROSIS

Osteoblast Osteoprotegerin (OPG) OPG, a soluble "decoy" receptor h o p y s i l g inhibits the recruitment, proliferation and activation of osteoclasts by binding to and neutralizing the OPG-L OPG ligand (OPG-L) Osteoblast (the bone forming cell) 11/8/2018 OSTEOPOROSIS

(the bone forming cell) OPG ligand (OPG-L) Osteoprotegerin (OPG) Osteoporosis … too many OPG-Ligands P a t h o p y s i l g Osteoblast (the bone forming cell) 11/8/2018 OSTEOPOROSIS