Familial Clustering of Barrett's Esophagus and Esophageal Adenocarcinoma in a European Cohort  Romy E. Verbeek, Lisanne F. Spittuler, Anique Peute, Martijn G.H. van Oijen, Fiebo J. ten Kate, Jacob R. Vermeijden, Ardi Oberndorff, Jantine W.P.M. van Baal, Peter D. Siersema  Clinical Gastroenterology and Hepatology  Volume 12, Issue 10, Pages 1656-1663.e1 (October 2014) DOI: 10.1016/j.cgh.2014.01.028 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Flowchart. Definitive familial BE: histologically confirmed diagnosis of BE or EAC in ≥1 first- or second-degree relatives of index patients with BE or EAC. Possible familial BE: relatives reportedly affected with BE or esophageal cancer, which could not be confirmed in the pathology registry. Unlikely familial BE: a reported or histologically confirmed negative family history of BE or esophageal cancer. Unknown: family history reported as unknown. *Number of families with confirmed diagnoses of BE, EAC (± BE), and both BE and EAC. **Number of families with reported diagnoses of BE, esophageal cancer, and both BE and esophageal cancer. Clinical Gastroenterology and Hepatology 2014 12, 1656-1663.e1DOI: (10.1016/j.cgh.2014.01.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Confirmation of diagnosis of relatives. *Diagnosis reported by index patient. **Confirmed histologic diagnosis. SCC, squamous cell carcinoma. Clinical Gastroenterology and Hepatology 2014 12, 1656-1663.e1DOI: (10.1016/j.cgh.2014.01.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Number of affected relatives per family. Total number of positive relatives with BE or EAC within a family in addition to the index patient in definitive familial BE subdivided into first- and second-degree relatives. Total number of families = 39. Clinical Gastroenterology and Hepatology 2014 12, 1656-1663.e1DOI: (10.1016/j.cgh.2014.01.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 4 Diagnosis of affected cases. Diagnoses of positive cases depicted per number of positive cases within a family, the index patients included. Total number of families = 39. Clinical Gastroenterology and Hepatology 2014 12, 1656-1663.e1DOI: (10.1016/j.cgh.2014.01.028) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 Pedigrees of families with multiple affected cases. (A) EAC was diagnosed in 2 brothers and in a maternal uncle and grandmother of a BE index patient. Two additional relatives underwent upper endoscopy. (B) EAC was diagnosed in a brother and father and in a paternal uncle and aunt of a BE index patient. Two additional relatives underwent upper endoscopy, and one was known to have reflux symptoms. Clinical Gastroenterology and Hepatology 2014 12, 1656-1663.e1DOI: (10.1016/j.cgh.2014.01.028) Copyright © 2014 AGA Institute Terms and Conditions