Neuropeptide S and Reward

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Presentation transcript:

Neuropeptide S and Reward

Is something rewarding? Will they self administer? Most self admin for cocaine If you shut down the reward system, do they stop self admin?

Wistar Rats All NPS injections into ventricle Hits WHOLE brain Angiotensin to confirm

N P S Vehicle N P S Vehicle Day 1 2 3 4 5 6 7 8

Animals will self administer NPS Suggests NPS is rewarding Self Administration NPS

Dopamine (DA) and Reward NPSR mRNA expressed in VTA – NOT in NAcc Xu 2007 VTA NAcc DA D1 GABA = NPSR mRNA found here

Dopamine antagonism reduces NPS self administration Reward system (DA) Self Administration NPS

NPS & Hypocretin ICV NPS → ↑Orx neuron activity (cfos) Cannella 2013 NPSR mRNA in hypothalamus containing Orx neurons Xu 2007

Hypocretin and Reward VTA NAcc D1 GABA LH = NPSR mRNA found here

Orexin antagonism reduces NPS self administration

Conditioned Place Preference (CPP)

The CPP thing N P S

Cannella 2013

Locomotion

Cue assisted lever pressing A light was used in conjunction with the lever Works better Responding to light or NPS Also.. NPS increases locomotion More lever pressing?

I SAID ONION PIZZA DAMNIT!!! (Thanks Justin)