Randomized evaluation of fibrinogen vs placebo in complex cardiovascular surgery (REPLACE): a double-blind phase III study of haemostatic therapy N.

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Randomized evaluation of fibrinogen vs placebo in complex cardiovascular surgery (REPLACE): a double-blind phase III study of haemostatic therapy N. Rahe-Meyer, J.H. Levy, C.D. Mazer, A. Schramko, A.A. Klein, R. Brat, Y. Okita, Y. Ueda, D.S. Schmidt, R. Ranganath, R. Gill British Journal of Anaesthesia Volume 117, Issue 1, Pages 41-51 (July 2016) DOI: 10.1093/bja/aew169 Copyright © 2016 The Author(s) Terms and Conditions

Fig 1 Patient disposition. CTA, completer of transfusion algorithm (i.e. patients in whom the standardized treatment algorithm was adhered to); FCH, human fibrinogen concentrate; ITT, intention to treat. British Journal of Anaesthesia 2016 117, 41-51DOI: (10.1093/bja/aew169) Copyright © 2016 The Author(s) Terms and Conditions

Fig 2 First and second bleeding mass (median, interquartile range and range; a) and the timings of these assessments [mean (sd); b]. BM, bleeding mass; CPB, cardiopulmonary bypass; FCH, human fibrinogen concentrate. British Journal of Anaesthesia 2016 117, 41-51DOI: (10.1093/bja/aew169) Copyright © 2016 The Author(s) Terms and Conditions

Fig 3 Transfusion of allogeneic blood products within 24 h of administering study medication. (a) Median, interquartile range and range. (b) Variability by pooled centre. *Austria, Denmark, Finland, Germany, Italy, and Poland. FCH, human fibrinogen concentrate. British Journal of Anaesthesia 2016 117, 41-51DOI: (10.1093/bja/aew169) Copyright © 2016 The Author(s) Terms and Conditions

Fig 4 Changes through time in plasma fibrinogen concentration (measured by the Clauss assay; a) and FIBTEM MCF (b). Error bars represent interquartile ranges. CPB, cardiopulmonary bypass; FCH, human fibrinogen concentrate; MCF, maximum clot firmness. British Journal of Anaesthesia 2016 117, 41-51DOI: (10.1093/bja/aew169) Copyright © 2016 The Author(s) Terms and Conditions