Inherited Disorders of Bilirubin Transport and Conjugation: New Insights Into Molecular Mechanisms and Consequences Serge Erlinger, Irwin M. Arias, Daniel.

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Presentation transcript:

Inherited Disorders of Bilirubin Transport and Conjugation: New Insights Into Molecular Mechanisms and Consequences Serge Erlinger, Irwin M. Arias, Daniel Dhumeaux Gastroenterology Volume 146, Issue 7, Pages 1625-1638 (June 2014) DOI: 10.1053/j.gastro.2014.03.047 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Schematic representation of the UGT1A1 locus and UGT1A1 protein. Gastroenterology 2014 146, 1625-1638DOI: (10.1053/j.gastro.2014.03.047) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Schematic view of bilirubin transport by the hepatocyte. (Inset) Localization of UGT1A1 in the reticulum endoplasmic membrane and transport of uridine diphospho-glucuronic acid (UDPGA), bilirubin, and bilirubin glucuronide across the endoplasmic reticulum membrane. UCB, unconjugated bilirubin; Alb, albumin; BG, bilirubin glucuronide. Gastroenterology 2014 146, 1625-1638DOI: (10.1053/j.gastro.2014.03.047) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Schematic view of the transporters involved in inherited disorders of bilirubin metabolism. UCB, unconjugated bilirubin; Alb, albumin; BG, bilirubin glucuronide. Gastroenterology 2014 146, 1625-1638DOI: (10.1053/j.gastro.2014.03.047) Copyright © 2014 AGA Institute Terms and Conditions