Volume 63, Issue 1, Pages (January 2003)

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Volume 63, Issue 1, Pages 209-216 (January 2003) Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes1 Ricardo Utimura, Clarice Kazue Fujihara, Ana Lúcia Mattar, Denise Maria Avancini Costa Malheiros, Irene de Lourdes Noronha, Roberto Zatz Kidney International Volume 63, Issue 1, Pages 209-216 (January 2003) DOI: 10.1046/j.1523-1755.2003.00736.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Body weight (A), blood glucose concentration (B) and urine albumin excretion rate (C) as a function of time in the control (C; ○), diabetes mellitus (DM; •) and DM + mycophenolate mofetil (MMF; ▪) gorups. Error bars represent SE. aP < 0.05 vs. C; bP < 0.05 vs. DM. Kidney International 2003 63, 209-216DOI: (10.1046/j.1523-1755.2003.00736.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Representative glomeruli in control (A), DM (B) and DM+MMF (C) rats. (Periodic acid-Schiff staining, original magnification ×200). Kidney International 2003 63, 209-216DOI: (10.1046/j.1523-1755.2003.00736.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Macrophages identified by ED-1 monoclonal antibody immunostaining in the glomerular area (indicated by the arrows) in control (A), DM (B), and DM+MMF (C) rats. (Original magnification ×400). Kidney International 2003 63, 209-216DOI: (10.1046/j.1523-1755.2003.00736.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Glomerulosclerosis index (GSI) in the C, DM and DM+MMF groups. Values are presented as mean ± 1 SE; *P < 0.05 vs. C; †P < 0.05 vs. DM. Kidney International 2003 63, 209-216DOI: (10.1046/j.1523-1755.2003.00736.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 Macrophage density in the glomerular area in the C, DM and DM+MMF at two months (▪) and eight months (□). Values are presented as mean ± 1 SE. *P < 0.05 vs. C; †P < 0.05 vs. DM for the same time point. Kidney International 2003 63, 209-216DOI: (10.1046/j.1523-1755.2003.00736.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 6 Lymphocyte density in the renal cortex at eight months in the C, DM and DM+MMF groups. Kidney International 2003 63, 209-216DOI: (10.1046/j.1523-1755.2003.00736.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 7 GSI exhibited significant linear correlation with the density of macrophages in the glomerular area (r2 = 0.49, P < 0.001). Kidney International 2003 63, 209-216DOI: (10.1046/j.1523-1755.2003.00736.x) Copyright © 2003 International Society of Nephrology Terms and Conditions