Volume 13, Issue 13, Pages R514-R516 (July 2003)

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Volume 13, Issue 13, Pages R514-R516 (July 2003) Synaptic Plasticity: Importance of Proteasome-Mediated Protein Turnover Hollis Cline Current Biology Volume 13, Issue 13, Pages R514-R516 (July 2003) DOI: 10.1016/S0960-9822(03)00443-3

Figure 1 The ubiquitin-proteasome system. (A) A substrate protein (S) is bound to ubiquitin (Ub) through the sequential activities of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2) and a ubiquitin ligase (E3). Polyubiquitinated proteins are degraded by the proteasome, which has two 19S subunits and a 20S subunit. (B) A diagram illustrating the pleotropic effects of protein synthesis and protein degradation on multiple parameters in neurons which affect synaptic plasticity. Current Biology 2003 13, R514-R516DOI: (10.1016/S0960-9822(03)00443-3)