Different ubiquitin linkage types and their role in immune signallingUbiquitin, a small protein of 76 amino acids, can be attached to a substrate protein.

Slides:

Advertisements

Similar presentations

Molecular Graphics Perspective of Protein Structure and Function.

Advertisements

Amino Acids: Disposal of Nitrogen

The ubiquitin system and a putative stimulatory role for activator turnover in gene expression Chao Wang Nov 16, 2005.

Amino acid residues in peptides and proteins are linked together through a covalent bond called the peptide bond. Two amino acid molecules can be covalently.

1. Primary Structure: Polypeptide chain Polypeptide chain Amino acid monomers Peptide linkages Figure 3.6 The Four Levels of Protein Structure.

Amino acid side chains stabilise the enzyme shape.

Proteolytic Cleavage Removal of the N-terminal methionine and/or other peptides from a proprotein. Acylation The initiator methionine is hydrolyzed and.

Amino acid residues in peptides and proteins are linked together through a covalent bond called the peptide bond. Two amino acid molecules can be covalently.

Chemistry: An Introduction to General, Organic, and Biological Chemistry, Twelfth Edition© 2015 Pearson Education, Inc Protein Synthesis In the translation.

Protein Metabolism 1  Denotes the various biochemical processes responsible for the synthesis of proteins and amino acids tthe breakdown of proteins.

Chemsheets AS006 (Electron arrangement)

Protein Turnover and Amino Acid Catabolism. The Digestion and Absorption of Dietary Proteins Pepsin nonspecific maximally active at low pH of the stomach.

Polypetides and proteins

Protein Synthesis Student Animations Copy the next slide if you need to to give you the diagrams needed to explain Transcription and Translation. Then.

PROTEIN SYNTHESIS THE FORMATION OF PROTEINS USING THE INFORMATION CODED IN DNA WITHIN THE NUCLEUS AND CARRIED OUT BY RNA IN THE CYTOPLASM.

Amino acids. Essential Amino Acids 10 amino acids not synthesized by the body arg, his, ile, leu, lys, met, phe, thr, trp, val Must obtain from the diet.

Proteins & DNA. Amino Acids: the building blocks of Proteins.

Uncommon amino acids, amino acids forming proteins, and primary structure of a protein Sections By Melissa Myers, Caroline Stepanik, and Jade.

Molecules, Gene and disease Session 1 Lecture 2 Amino acids and protein.

Protein Metabolism Denotes the various biochemical processes responsible for the synthesis of proteins and amino acids the breakdown of proteins (and other.

Ubiquitin By Mr. Szerminski Sample 4U CCT. Topics to be discussed General info: - it is a regulatory protein that has been found in almost all tissues.

Chapter 14. Examples of Homonuclear 2D Experiments.

Amine R group Alpha Carbon Carboxylic Acid. Nonpolar side chains.

Protein chemistry Lecture Amino acids are the basic structural units of proteins consisting of: - Amino group, (-NH2) - Carboxyl group(-COOH)

Analysis Of Microarray Data By Harsha Nilakantan & Mihir Solanki.

KikG structure (Protein Data Bank accession code 1XSS).

The determinants of the interswitch toggle.

Statistical analysis of transgene expression in pigs generated by lentiviral gene transfer. Statistical analysis of transgene expression in pigs generated.

Positioning of the TGF‐β3 and BMP receptor complexes on a membrane surface. Positioning of the TGF‐β3 and BMP receptor complexes on a membrane surface.

Diversity of Polyubiquitin Chains

(A, B) Stereoscopic views of the P3 RNase MRP RNA domain in complex with the RNase MRP/RNase P protein components Pop6 and Pop7. (A, B) Stereoscopic views.

Protein sequences and three‐dimensional structures of HUB1 (homologous to ubiquitin 1), ubiquitin and ubiquitin‐like modifiers. Protein sequences and three‐dimensional.

Yeast Tgl3p expressed in HeLa cells localizes to lipid droplets.

Control of blood proteins by functional disulfide bonds

1,25‐dihydroxyvitamin D3 and retinoic acid induce p19ink4d expression.

Face‐to‐face kinase domain dimerisation of human Ire1α.

Amino‐acid sequence of the heterogeneous nuclear RNP G protein family and RNA‐binding SELEX consensus sequence obtained for human RBMY. (A) Sequence alignment.

Metabolism of amino acids, porphyrins

Sequence and comparison of the SDS protein.

AAV viral constructs and Rep expression plasmids.

Structure of the mouse stomatin domain.

Ubiquitination Accomplished: E1 and E2 Enzymes Were Not Necessary

MCM3AP‐mediated acetylation of MCM3.

Ubiquitin and immune system modulationCells of both the innate and adaptive arms of the immune system are crucial for immune reactivity and self‐tolerance.

Crystal structure of the Atg12–Atg5 conjugate bound to Atg16N.

Structure of in‐frame deletions.

Biomolecules Nutrient Sort Biology 12.

Schematic diagram of ubiquitin and SUMO modification pathways

Amino Acids An amino acid is any compound that contains an amino group (—NH2) and a carboxyl group (—COOH) in the same molecule.

The production of reduced or oxidized glutathione can occur at various stages during the formation of native disulphide bonds. The production of reduced.

The MSP domain of MOSPD2 binds the FFAT motif

MOSPD2 is a putative tail‐anchored protein

Ubiquitin Recognition by the Human TSG101 Protein

Mechanism of Triton binding to ShHTL7

Usp5 sensitivity of S65 ubiquitin mutant chains Structure of ubiquitin in complex with Usp5 (PDB ID: 3IHP). Usp5 sensitivity of S65 ubiquitin mutant chains.

Ubiquitin code assembly and disassembly

PAA binds to ShHTL7 and inhibits Striga germination and the structural requirement for ShHTL7 to accommodate its substrate PAA binds to ShHTL7 and inhibits.

Sequence alignment of PHCCEx domains with secondary structure elements of the Tiam2 PHCCEx domain at the top. Sequence alignment of PHCCEx domains with.

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

CUL3Δ403–459 displays increased auto‐ubiquitylation and ubiquitylation of KLHL3 A–DIn vitro ubiquitylation assays with purified proteins. CUL3Δ403–459.

CD44 binding surface of the Tiam2 PHCCEx domain.

Secondary‐structure‐weighted sequence alignment of TssF1 with the N‐terminal region of gp6 and TssG1 with gp53 Secondary‐structure‐weighted sequence alignment.

WES identification of heterozygous compound mutations in ALPI

Keeping p53 in Check: A High-Stakes Balancing Act

WES identification of heterozygous compound mutations in ALPI

Characterization of GDF11 signalling through type I and type II receptors. Characterization of GDF11 signalling through type I and type II receptors. Gene.

Chapter Proteins and Enzymes

Figure 1. Schematic drawing of seven IL-32 variants with gradated protein map. Seven IL-32 variants are composed of eleven protein domains. The longest.

Presentation transcript:

Different ubiquitin linkage types and their role in immune signallingUbiquitin, a small protein of 76 amino acids, can be attached to a substrate protein or to a ubiquitin molecule that is already attached to a substrate, with the latter resulting in an inter‐ubiquitin linkage. Different ubiquitin linkage types and their role in immune signallingUbiquitin, a small protein of 76 amino acids, can be attached to a substrate protein or to a ubiquitin molecule that is already attached to a substrate, with the latter resulting in an inter‐ubiquitin linkage. Attachment to substrates will typically occur through an isopeptide bond between the ε‐amino group of a lysine residue (K) within the substrate protein and the C‐terminal carboxyl group of glycine 76 (G76) of ubiquitin. Inter‐ubiquitin linkages are usually between the ε‐amino group of one of the seven internal lysine residues (K6, K11, K27, K29, K33, K48 and K63) of the substrate‐associated acceptor ubiquitin and the carboxyl group of G76 of the incoming ubiquitin2. Another type of inter‐ubiquitin linkage can be formed between the α‐amino group of the N‐terminal methionine 1 (M1) of the substrate‐associated ubiquitin and the carboxyl group of G76 of the incoming ubiquitin. The resulting linkage type is called M1‐ or linear linkage. Different inter‐ubiquitin linkage types fulfil different functions in immune signalling. The functions currently attributed to the different linkage types are summarised in the respective boxes. Removal of ubiquitin is carried out by DUBs, which have recently been shown to specifically cleave certain linkage types, for example CYLD cleaves K63‐ and M1–linkages. Julia Zinngrebe et al. EMBO Rep. 2014;15:28-45 © as stated in the article, figure or figure legend