Joint Changes in Protein and Ligand Flexibility Upon Substrate Recognition Lab of Jeffrey W. Peng, University of Notre Dame, Dept of Chemistry and Biochemistry.

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Joint Changes in Protein and Ligand Flexibility Upon Substrate Recognition Lab of Jeffrey W. Peng, University of Notre Dame, Dept of Chemistry and Biochemistry 251 Nieuwland Science Hall, Notre Dame, IN 46556 Mobility profile for CaH bonds of substrate peptide EQPLpTPVTDL +/- Pin1 Lower-bars = enhanced ps-ns mobility Higher-bars = enhanced us-ms mobility Pin1: Red = internal conduit of “stiffening” connecting domain-domain interface to the catalytic site. Stiffening caused by substrate peptide binding (on the left).