Moles and Molar Mass Objective: I will be able to convert moles of a substance to mass and mass to moles. Entry Task: The LD50 for arsenic (III) oxide, As2O3, is 15 mg/kg. Figure out the lethal dose for a 150 lb adult (1 kg = 2.2 lb) How many molecules do you think are in a lethal dose? What would you need to know to figure this out?
Mass of an atom, mass of a mole of atoms Atomic mass of 1 atom (from periodic table): Mass of C = 12.011 amu Mass of As = 74.922 amu Mass of O = 16 amu Actual mass of 1 mole: Mass of 1 mol C atoms = 12.011 g Mass of 1 mol As atoms = 74.922 g Mass of 1 mol O atoms = 16 g
Mass of molecules Atomic Mass of Molecules (add mass of all atoms): Mass of CO2 = 12.011 + 16 + 16 = 44.011 amu Mass of As2O3 = 74.922+74.922+16+16+16 = 198.844 amu 1 mol of CO2 = 1 mole of C atoms and 2 moles of O atoms 1 mol of As2O3 = 2 moles of As atoms and 3 moles of O atoms Actual mass of 1 mole: Mass of 1 mol CO2 = 12.011 + 16 + 16 = 44.011 g Mass of 1 mol As2O3 = 74.922+74.922+16+16+16 = 198.844 g
What is the mass of 1 molecule of... PbCl2 = H2O = C12H22O11 = CaCO3 = 207.2+35.453+35.453 = 278.106 amu 1.01+1.01+16 = 18.02 amu 12(12.011) + 22(1.01) + 11(16) = 342.352 amu 40.078+12.011+16+16+16= 100.089 amu
What is the mass of 1 MOLE of... PbCl2 = H2O = C12H22O11 = CaCO3 = 207.2+35.453+35.453 = 278.106 g 1.01+1.01+16 = 18.02 g 12(12.011) + 22(1.01) + 11(16) = 342.352 g 40.078+12.011+16+16+16= 100.089 g Mass of 1 mole of a substance is known as the MOLAR MASS
What are the Molar Masses of: Name of drug Chemical formula Molar Mass Adult dose Moles in adult dose? acetomen-iphen C8H9NO2 500 mg aspirin C9H8O4 325 mg ibuprofen C13H18O2 400 mg 151.2 g 0.0033 mol 180.2 g 0.0018 mol 206.3 g 0.0019 mol
Moles-Mass conversions Mass to moles: # of moles (mol) = mass(g) / molar mass(g/mol) Moles to mass: mass(g) = # of moles(mol) x molar mass(g/mol) I have an 11g sample of Cl2. How many moles do I have? I have 3.0 moles of MgO. What mass does the sample have? 11g / 70.906(g/mol) = 0.16 mol 3 mol x 40.305(g/mol) = 120.915 g
Exit Ticket Methadone is a medication used as a painkiller and as a treatment for those recovering from heroin addiction. The LD50 for methadone is 95 mg/kg. Would you consider methadone to be more or less toxic than acetomenaphen (LD50 = 2404 mg/kg)? Than aspirin (LD50 = 200 mg/kg)? Explain how you would calculate the amount of methadone that would be lethal to a human.