Gamma Knife Radiosurgery

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Presentation transcript:

Gamma Knife Radiosurgery By: Tou Hmong Khang Biomedical Engineering BME 281 Section 1

Background Also known as Stereotactic Radiosurgery Type of radiation treatment used commonly for brain tumors and other abnormalities of the head Investigated in the 1950s by Dr. Borje Larsson and Dr. Lars Leksell First Gamma Knife device constructed in 1967 Requires no incisions

Leksell Gamma Knife Perfexion

Device Operation Focuses and delivers 192 beams to target tumor/lesion etc. Collimator 4mm, 8mm and 16mm Radiation only distorts and destroys abnormal cells Long term affect

Collimator

What it looks likes

General Procedures Head Frame Imaging Treatment Planning Treat

Post Treatment On average with in about a day Back to normal activities Receive Follow up appointments with Doctor

Case Study: Acoustic Neuroma 75-year-old woman Left-sided tinnitus and progressive sensorineural hearing loss MRI scans revealed 2.7 cc left-sided enhancing mass Acoustic Neuroma

Before and After Results Treatment delivered in less than 1 hour Returned to normal activities later that day Semi-annual follow-up Improvement of tinnitus, functional hearing in left ear After three years, MRI reveals 0.5 cc residual mass Greater than 80% reduction in size

Cost of GKRS GKRS vs Open Surgery Across 3 years Average 12 month cost of Open surgery Brain metastases - $55,938 Acoustic Neuroma - $67,538 Arteriovenous Malformations (AVM) - $78,332 Average 12 month cost of GKRS Brain metastases - $23,069 Acoustic Neuroma - $37,840 Arteriovenous Malformations (AVM) - $46,293

Disadvantages Small risk of advertise radiation affects(2-4%) resulting in swelling Common Early Complications Rare Early Complications Rare Delayed Complications Long term affects not ideal for immediate affects

Conclusion Cost effective Better alternative to open surgery Possible whole body Gamma Knife Radiosurgery implementation

References [1] Gamma Knife Overview. (2015, November 16). <http://www.beaumontgammaknife.org/overview.html> [2] Gamma Knife Sugery: Pros and Cons. (2015, November 16). <http://www.odec.ca/projects/2006/cham6m2/prosandcons.html> [3] Caruso, JP, Moosa, S, Fezeu, F, Ramesh, A, Sheehan, JP. (2015, November 16). A cost comparative study of Gamma Knife radiosurgery versus open surgery for intracranial pathology. <http://www.ncbi.nlm.nih.gov/pubmed/25444994> [4]Taban, A. (2015, November 14). A gamma knifre case study: Acoustic Neuroma. <http://drashertaban.com/services-case-studies.php> [5] Gamma Knifre Radiosurgery. (2015, November 14). <http://www.columbianeurosurgery.org/conditions/gamma-knife-radiosurgery/> [6]Niranjan, A. (2015, November 14). Gamma Knife Radiosurgery: Current Technique. <http://www.wfns.org/pages/read_the_reviews/97.php?rid=52> [7] The Gamma Knifre: A Technical Overview. (2015, November 14). <http://www.medicine.virginia.edu/clinical/departments/neurosurgery/gammaknife/overview-page> [8] MayoClinic: Brain Stereotactic radiosurgery. (2015, November 14). <http://www.mayoclinic.org/tests-procedures/brain-stereotactic-radiosurgery/basics/definition/prc-20014760> [9] RWJ University Hospital. (2015, November 16). Gamma Knife. <http://www.rwjuh.edu/gamma-knife/gamma-knife-center.aspx>

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