The Fight Against Obesity as a Disease: Tackling the Core of the Condition.

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Presentation transcript:

The Fight Against Obesity as a Disease: Tackling the Core of the Condition

Introduction/Background

Global Prevalence of Obesity

Tracking the Global Obesity Epidemic

The Impact of Obesity Upon Individuals

Obesity as a Risk Factor for a Range of Comorbid Conditions[a,b]

Estimated Number of Cancer Cases (in Thousands) Attributable to Excess Body Mass

The Obesogenic Environment

Fixing the Obesogenic Environment

A Structured Program of Behavioral Change Is Beneficial for Weight Loss

Look AHEAD Weight Loss Maintenance

Dieting, and Energy Intake Regulation: The Dilemma

Mechanisms of Food Intake Regulation

Satiety Signaling and Inhibitory Control May Be Weaker in the Obesity-Prone

Weight Loss at End of Study vs Weight Loss at Follow-up

Weight Loss Improves Obesity-Related Comorbidities

Factors Driving Weight Regain or Weight Loss Maintenance after Initial Weight Loss

Proportion of Patients Achieving > 5% Weight Loss at Year 1: Liraglutide, Orlistat, Placebo

Percentage Weight Loss From Baseline for the Modified-ITT-LOCF Population and the Completer Population: Naltrexone + Bupropion vs Placebo

SCALE: Change in Body Weight (%), Liraglutide vs Placebo

SCALE Maintenance: Proportion of Patients Maintaining Run-In Weight Loss or Regaining ≥ 5% From Randomization to Week 56

NICE Guidelines for the Treatment of Overweight/Obesity

Weight Loss Surgery

Bariatric Surgery: Mechanisms of Action in Weight Loss

Bariatric Surgery Is Associated With Sustained Weight Loss Over 15 Years

Bariatric Surgery and T2DM Prevention or Remission

Bariatric Surgery and the Risk of "Addiction Transfer"

Conclusions

Abbreviations

Abbreviations (cont)