Figure 1 Lymphocytes during the disease

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Rheumatoid Arthritis(RA)

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Part B Autoimmune Diseases Part B Autoimmune Diseases Effector mechanisms of autoimmune disease Endocrine glands as special targets.

AUTOIMMUNITY. Self/Non-self Discrimination Autoimmunity is a problem of self/non-self discrimination.

Tissue Repair and Tissue Disorders. Replacing old/worn out tissue New cells generate by mitosis from the stroma (supporting connective tissue) or the.

Physiological Diseases of the human Skeleton. Inflammatory Disorders of joints Joint pain and discomfort can be caused by many factors Bursitis Arthritis.

R HEUMATOID F ACTOR ( RF ). Rheumatoid arthritis is a chronic inflammatory disorder that affects all joints either in hands or feet and other areas of.

Acute Inflammation (recruitment of neutrophils).

AUTOIMMUNITY AND AUTOIMMUNE DISEASE

Failures against ‘self’ (Principles of Autoimmunity)

Cellular components in RA joints Synovial membrane with synovial lining cells Cartilage Joint capsule Inflamed, thick synovial membrane Invading.

Figure 1 Role of innate lymphoid cells (ILCs) in steady state,

AUTOIMMUNE DISEASES.

Nat. Rev. Rheumatol. doi: /nrrheum

of different experimental arthritis models

Figure 3 The adaptive and maladaptive energy matrices

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Figure 3 Example of how a noncoding regulatory rheumatoid

Figure 3 Connexins in cartilage

Figure 1 Historical evolution of the clinical classification and

Figure 2 A timeline summarizing the development of diagnostic tools in rheumatology Figure 2 | A timeline summarizing the development of diagnostic tools.

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Clinical and microbiological aspects of periodontitis

Figure 1 Enthesitis versus synovitis

Nat. Rev. Rheumatol. doi: /nrrheum

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Figure 1 Induction of immune tolerance

Figure 4 Ex vivo synovial tissue culture viability

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Figure 3 Transcriptome studies performed in the target

Figure 2 Shared genetic loci in systemic autoimmune diseases

Figure 1 Location of HLA variants known to be associated

Nat. Rev. Nephrol. doi: /nrneph

Figure 3 Strategies to achieve therapeutic inhibition of IL-1

Figure 2 Type 3 immunity and AS

Figure 2 Interaction effects between heterozygous HLA‑DRB1

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Statistical approaches for the analysis of metabolomic data

Figure 6 Lack of IRF5 causes a reduction in neutrophil influx

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 5 The role of Ly6Chi and Ly6Clo monocytes

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Multi-hit model for autoimmune diseases

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Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Emerging hallmarks of T cells in rheumatoid arthritis

Autoimmunity through Cytokine-Induced Dendritic Cell Activation

Figure 1 Treat to target, remission and low disease activity in SLE

Figure 1 The current model of the pathogenesis of SLE

Figure 6 Metabolism of pterins

Figure 1 Principles for the diagnosis and management of osteoarthritis

Figure 2 GM-CSF — a key player in inflammation and autoimmunity

Figure 2 Embryonic origins of tissue-resident macrophages

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Chronic inflammation and DNA damage in people with SLE

Figure 2 Phenotypes of osteoarthritis

Figure 1 Differential effects of bone-forming agents on bone surfaces

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Patterns of joint and organ involvement in rheumatic disease

Figure 4 Role of chemokines in dendritic cell migration

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 The role of macrophages in RA

Figure 2 Involvement of plasmacytoid dendritic cells

Presentation transcript:

Figure 1 Lymphocytes during the disease process of rheumatoid arthritis in different tissue environments Figure 1 | Lymphocytes during the disease process of rheumatoid arthritis in different tissue environments. The disease process of rheumatoid arthritis (RA) involves multiple tissue environments and extends over several decades. An early event is the breakdown of immunologic tolerance, which occurs in lymphoid tissues. After expansion and maturation of autoreactive lymphocytes, autoantigens are encountered in peripheral tissues, eventually leading to the formation of tertiary lymphoid microstructures and chronic destructive inflammation. The inflamed synovial membrane and the disrupted tissue repair response represent the end stage of RA. Weyand, C. M. & Goronzy, J. J. (2017) Immunometabolism in early and late stages of rheumatoid arthritis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.49