Impact of probiotics on colonic microflora in patients with colitis: A prospective double blind randomised crossover study  Jamil Ahmed, Bala S. Reddy,

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Impact of probiotics on colonic microflora in patients with colitis: A prospective double blind randomised crossover study  Jamil Ahmed, Bala S. Reddy, Lars Mølbak, Thomas D. Leser, John MacFie  International Journal of Surgery  Volume 11, Issue 10, Pages 1131-1136 (December 2013) DOI: 10.1016/j.ijsu.2013.08.019 Copyright © 2013 Surgical Associates Ltd Terms and Conditions

Fig. 1 Study design. International Journal of Surgery 2013 11, 1131-1136DOI: (10.1016/j.ijsu.2013.08.019) Copyright © 2013 Surgical Associates Ltd Terms and Conditions

Fig. 2 T-RFLP gel and a complete comparison dendrogram based on a dice analysis. Each patient had an average of 72% pairwise similarity independent of treatment, whereas the pairwise similarity among the different patients had an average of 55%. International Journal of Surgery 2013 11, 1131-1136DOI: (10.1016/j.ijsu.2013.08.019) Copyright © 2013 Surgical Associates Ltd Terms and Conditions

Fig. 3 Relative abundance values for terminal restriction fragments (T-RFs) obtained by using general bacterial primers and HhaI restriction digestion. International Journal of Surgery 2013 11, 1131-1136DOI: (10.1016/j.ijsu.2013.08.019) Copyright © 2013 Surgical Associates Ltd Terms and Conditions

Fig. 4 B. fragilis DNA concentrations in samples from patients with Crohn's (CD), or ulcerative colitis (UC). Concentration at entry level (A), concentration at two other sampling points (B, or C). Sampling after probiotic treatment is indicated by black bars. International Journal of Surgery 2013 11, 1131-1136DOI: (10.1016/j.ijsu.2013.08.019) Copyright © 2013 Surgical Associates Ltd Terms and Conditions

Fig. 5 Abundance of B. fragilis. Correlation between abundance of B. fragilis- DNA determined by T-RFLP and Q-PCR. International Journal of Surgery 2013 11, 1131-1136DOI: (10.1016/j.ijsu.2013.08.019) Copyright © 2013 Surgical Associates Ltd Terms and Conditions

Graph 1 Harvey Bradshaw index. International Journal of Surgery 2013 11, 1131-1136DOI: (10.1016/j.ijsu.2013.08.019) Copyright © 2013 Surgical Associates Ltd Terms and Conditions

Graph 2 Harvey Bradshaw index. International Journal of Surgery 2013 11, 1131-1136DOI: (10.1016/j.ijsu.2013.08.019) Copyright © 2013 Surgical Associates Ltd Terms and Conditions

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