A Novel Link between Inflammation and Cancer Yenkel Grinberg-Bleyer, Sankar Ghosh  Cancer Cell  Volume 30, Issue 6, Pages 829-830 (December 2016) DOI: 10.1016/j.ccell.2016.11.013 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Regulation and Role of PD-L1 Expression in Cancer Cells The proinflammatory tumor microenvironment promotes transcriptional and post-translational upregulation of PD-L1, maintaining checkpoint blockade. Activation of NF-κB, IRF, and STAT family transcription factors increases transcription of the Cd274 gene encoding PD-L1. NF-κB activation, for example downstream of TNF binding to TNFR1, directly induces expression of the COPS5 gene encoding CSN5, which deubiquitinates and stabilizes PD-L1 protein. Cancer Cell 2016 30, 829-830DOI: (10.1016/j.ccell.2016.11.013) Copyright © 2016 Elsevier Inc. Terms and Conditions