EHT, a New Member of the MTG8/ETO Gene Family, Maps on 20q11 Region and Is Deleted in Acute Myeloid Leukemias by Nicola Stefano Fracchiolla, Gualtiero.

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EHT, a New Member of the MTG8/ETO Gene Family, Maps on 20q11 Region and Is Deleted in Acute Myeloid Leukemias by Nicola Stefano Fracchiolla, Gualtiero Colombo, Palma Finelli, Anna Teresa Maiolo, and Antonino Neri Blood Volume 92(9):3481-3484 November 1, 1998 ©1998 by American Society of Hematology

Nicola Stefano Fracchiolla et al. Blood 1998;92:3481-3484 ©1998 by American Society of Hematology

Nicola Stefano Fracchiolla et al. Blood 1998;92:3481-3484 ©1998 by American Society of Hematology

(A) Analysis of EHT gene in AML cases by quantitative Southern blot: cases AML11, 12, 22, and 24 show a loss of signal with respect to the control probe (PFL-1 probe for Bcl-2 gene). (A) Analysis of EHT gene in AML cases by quantitative Southern blot: cases AML11, 12, 22, and 24 show a loss of signal with respect to the control probe (PFL-1 probe for Bcl-2 gene). Because the percentage of leukemia cells in all cases is greater than 70%, this finding is consistent with an homozygous deletion. The probe (EHT3′) was specific for the 3′ UTR of EHT. (B) EHT gene expression analysis. Poly-A+ Northern blot filters (Clontech), were hybridized with the EHT3′ probe. The two dashes indicate the molecular weight (9.5 and 7.5 kb). The two transcripts were not represented in all of the tissues at the same level; in the testis, heart, brain, and skeletal muscle, the lower transcript was particularly expressed. Nicola Stefano Fracchiolla et al. Blood 1998;92:3481-3484 ©1998 by American Society of Hematology