Stem cell therapeutic possibilities: future therapeutic options for male-factor and female- factor infertility? Charles A. Easley, Calvin R. Simerly,

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Presentation transcript:

Stem cell therapeutic possibilities: future therapeutic options for male-factor and female- factor infertility? Charles A. Easley, Calvin R. Simerly, Gerald Schatten Reproductive BioMedicine Online Volume 27, Issue 1, Pages 75-80 (July 2013) DOI: 10.1016/j.rbmo.2013.03.003 Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Using human pluripotent stem cells to treat infertility. Male (top) and female (bottom) infertility could be treated by deriving patient-specific induced pluripotent stem cells (iPSC) from patient somatic cell samples. For males, these iPSC can be differentiated into spermatogonial stem cells (SSC) for transplantation into the testis to recolonize and generate spermatozoa in vivo. iPSC can also be differentiated in vitro into haploid cell products capable of fertilizing an oocyte by IVF. Similarly, female iPSC can be differentiated in vitro into oocytes capable of being fertilized by a partner’s spermatozoa to produce offspring by IVF. Reproductive BioMedicine Online 2013 27, 75-80DOI: (10.1016/j.rbmo.2013.03.003) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions