Clinical features of patients isolated for suspected Ebola virus disease at Connaught Hospital, Freetown, Sierra Leone: a retrospective cohort study  Dr Marta Lado, MD, Naomi F Walker, MRCP, Peter Baker, MBChB, Shamil Haroon, MPH, Colin S Brown, MBChB, Daniel Youkee, MBBS, Neil Studd, MBBS, Quaanan Kessete, Rishma Maini, MBChB, Tom Boyles, Cert ID SA, Eva Hanciles, FWACS, Alie Wurie, MD, Thaim B Kamara, FWACS, Oliver Johnson, MBBS, Andrew J M Leather, MS  The Lancet Infectious Diseases  Volume 15, Issue 9, Pages 1024-1033 (September 2015) DOI: 10.1016/S1473-3099(15)00137-1 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Study population and case classification The source population was all patients presenting at (or referred to) Connaught Hospital from March 31, 2014, to Dec 8, 2014. Suspected cases of Ebola virus disease were identified from these patients by the suspected Ebola virus disease case definition in use (panel) or by the Ebola virus disease screening device used from Oct 24, 2014, onwards (appendix p 5). All suspected cases were admitted to Connaught Hospital Ebola holding unit and comprised the study population. Patients in the study population were classified as Ebola virus disease cases if the result of EBOV RT-PCR test confirmed the diagnosis. Patients who tested negative by EBOV RT-PCR were designated non-cases and those without a recorded EBOV RT-PCR result were excluded. EBOV RT-PCR=Ebola virus reverse-transcriptase PCR. The Lancet Infectious Diseases 2015 15, 1024-1033DOI: (10.1016/S1473-3099(15)00137-1) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 2 Frequency of patients admitted to Connaught Hospital Ebola holding unit, by study week Frequency of patients admitted to Connaught Hospital Ebola holding unit by study week 1–28, starting from May 26, 2014. Red bars are patients in whom Ebola virus disease was confirmed by Ebola virus reverse-transcriptase PCR (EBOV RT-PCR; Ebola virus disease cases), blue bars are EBOV RT-PCR-negative patients (non-cases), and green bars represent those with unknown disease status. Admissions in study week 29 are not shown because it was an incomplete week. The Lancet Infectious Diseases 2015 15, 1024-1033DOI: (10.1016/S1473-3099(15)00137-1) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 3 Presenting features on admission at Connaught Hospital Ebola holding unit (A) Frequency of Ebola virus disease cases (patients in whom an Ebola virus disease diagnosis was confirmed by Ebola virus reverse-transcriptase PCR [EBOV RT-PCR] with each symptom) and non-cases (EBOV RT-PCR negative). (B) Diagnostic odds ratios (with 95% CIs, vertical error bars) for each presenting symptom for Ebola virus disease, in suspected cases. 95% CIs for jaundice and pain behind eye were not calculated because of small sample size. Major symptoms were defined as: vomiting, diarrhoea, intense fatigue, conjunctivitis, hiccups, confusion, presence of at least one risk factor for Ebola virus disease exposure (travel to an Ebola virus disease hotspot area, health-care work, contact with an ill family or friend, or funeral attendance). LOC=loss of consciousness. The Lancet Infectious Diseases 2015 15, 1024-1033DOI: (10.1016/S1473-3099(15)00137-1) Copyright © 2015 Elsevier Ltd Terms and Conditions