miR93 for the treatment of peripheral arterial disease (PAD)

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Presentation transcript:

miR93 for the treatment of peripheral arterial disease (PAD) Inventors: Brian H. Annex, MD, Dr. Surovi Hazarika, and Dr. Charles Farber University of Virginia Licensing & Ventures Group Director, Licensing: Patrick Klepcyk klepcyk@virginia.edu 434.982.1610

Peripheral artery disease (PAD) Peripheral arterial disease (PAD), or a narrowing or blockage of the blood vessels in the extremities, affects 8-12 million adults in the U.S. $4 billion spent annually on PAD-related treatment. Clinical Problem: As the population ages, the prevalence of PAD is expected to increase exponentially. Current treatments are mostly limited to either lifestyle changes to slow disease progression or (often invasive) surgeries and there is no definitive medical therapy to improve perfusion in the ischemic limb. Vascular Associates of Michigan 2 ANNEX-MIR93

miR93 Solution: Researchers at the University of Virginia have identified a micro-RNA, miR93, that plays a significant role in tissue adaption to ischemia and adaptive angiogenesis in PAD miR93 has the ability to modulate both endothelial and myocyte survival and promote angiogenesis Novel strategy for the treatment of PAD miR93 Circulation Research 3 ANNEX-MIR93

miR93 treatment shows improved perfusion recovery Premicro-RNA 93 treated mice showed significantly improved perfusion recovery compared with scramble-treated mice at day 14 and day 21 after hind leg ischemia (HLI). 4 ANNEX-MIR93

miR93 treatment shows significantly higher capillary density At day 21 after HLI, ischemic gastrocnemius muscle from premicro-RNA 93–treated mice showed significantly higher capillary density than scramble-treated mice. 5 ANNEX-MIR93

Relevant Publications Circulation. 2013 Apr 30;127(17):1818-28. Hazarika S, et. al. Nature Reviews Cardiology. 2013 Jul;10(7):387-96. Annex BH. 6 ANNEX-MIR93

Intellectual Property US 9,845,465 B2, issued 12/19/17 EP Application No 13829411.1 Intention to grant is imminent Amendments for allowed claims filed 1/3/18 Title: Compositions and methods for treating peripheral arterial disease 7 ANNEX-MIR93